Simvastatin Synthase (LovD)

PDB codes:

3HL9, from Aspergillus terreus, unliganded

3HLB, from Aspergillus terreus, unliganded, selenomet derivative

3HLC, from Aspergillus terreus, S5 mutant, uniganded

3HLD, from Aspergillus terreus, S5 mutant, complex with monacolin J acid

3HLE, from Aspergillus terreus, S5 mutant, S76A mutant, complex with monacolin J acid

3HLF, from Aspergillus terreus, S5 mutant, S76A mutant, complex with simvastatin

3HLG, from Aspergillus terreus, S5 mutant, S76A mutant, complex with lovastatin

Reference:

Gao, X., Xie, X., Pashkov, I., Sawaya, M. R., Laidman, J., Zhang, W., Cacho, R., Yeates, T. O., and Tang, Y. (2009) Directed evolution and structural characterization of a simvastatin synthase, Chem. Biol. 16, 1064-1074. PubMed

Beamline: 24-ID-C