Publications
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(2014) Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chem Biol. 21, 591-5
(2025) In vivo nucleotide excision repair by mycobacterial UvrD1 requires ATP hydrolysis but does not depend on cysteine disulfide-mediated dimerization and DNA unwinding. Nucleic Acids Res. 10.1093/nar/gkaf269
(2024) Structure and psoralen DNA crosslink repair activity of mycobacterial Nei2. mBio. 15, e0124824
(2020) Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. Structure. 10.1016/j.str.2020.01.005
(2025) Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif. Structure. 10.1016/j.str.2025.11.003
(2021) Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep. 10.15252/embr.202152675
(2021) Dual arginine recognition of LRRK2 phosphorylated Rab GTPases. Biophys J. 10.1016/j.bpj.2021.03.030
(2014) Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome. ACS Chem Biol. 9, 2621-31
(2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife. 10.7554/eLife.29062
(2019) Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 177, 1124-1135.e16
(2022) Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6. Biochemistry. 10.1021/acs.biochem.2c00332
(2019) Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc Natl Acad Sci U S A. 116, 17280-17289
(2023) Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen . Biochemistry. 62, 2689-2699
(2016) A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation. Cell Discov. 2, 16044
(2014) The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant. Proc Natl Acad Sci U S A. 111, E3756-65
(2015) Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature. 526, 723-7
(2005) Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. J Biol Chem. 280, 37041-7
(2025) CARD domains mediate anti-phage defence in bacterial gasdermin systems. Nature. 10.1038/s41586-024-08498-3
(2023) Insight into the mechanism of H-coupled nucleobase transport. Proc Natl Acad Sci U S A. 120, e2302799120
(2019) Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling. J Lipid Res. 60, 360-374
(2019) A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. Elife. 10.7554/eLife.40372

