Publications

Found 28 results
Filters: Author is Grant, Robert A  [Clear All Filters]
Journal Article
Wang, B., Dai, P., Ding, D., Del Rosario, A., Grant, R. A., Pentelute, B. L., and Laub, M. T. (2019) Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat Chem Biol. 15, 141-150
Sohn, J., Grant, R. A., and Sauer, R. T. (2007) Allosteric activation of DegS, a stress sensor PDZ protease. Cell. 131, 572-83
Sohn, J., Grant, R. A., and Sauer, R. T. (2010) Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J Biol Chem. 285, 34039-47
Mawla, G. D., Hall, B. M., Cárcamo-Oyarce, G., Grant, R. A., Zhang, J. Jia, Kardon, J. R., Ribbeck, K., Sauer, R. T., and Baker, T. A. (2020) ClpP1P2 peptidase activity promotes biofilm formation in P. aeruginosa. Mol Microbiol. 10.1111/mmi.14649
Tabtiang, R. K., Cezairliyan, B. O., Grant, R. A., Cochrane, J. C., and Sauer, R. T. (2005) Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure. Proc Natl Acad Sci U S A. 102, 2305-9
Kim, S., Grant, R. A., and Sauer, R. T. (2011) Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell. 145, 67-78
Baytshtok, V., Chen, J., Glynn, S. E., Nager, A. R., Grant, R. A., Baker, T. A., and Sauer, R. T. (2017) Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation. J Biol Chem. 292, 5695-5704
Shechner, D. M., Grant, R. A., Bagby, S. C., Koldobskaya, Y., Piccirilli, J. A., and Bartel, D. P. (2009) Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science. 326, 1271-5
Dutta, S., Gullá, S., T Chen, S., Fire, E., Grant, R. A., and Keating, A. E. (2010) Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol. 398, 747-62
Jenson, J. M., Ryan, J. A., Grant, R. A., Letai, A., and Keating, A. E. (2017) Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife. 10.7554/eLife.25541
Baytshtok, V., Fei, X., Shih, T. - T., Grant, R. A., Santos, J. C., Baker, T. A., and Sauer, R. T. (2021) Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep. 34, 108639
Ahmad, S., Wang, B., Walker, M. D., Tran, H. - K. R., Stogios, P. J., Savchenko, A., Grant, R. A., McArthur, A. G., Laub, M. T., and Whitney, J. C. (2019) An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature. 575, 674-678
Araghi, R. Rezaei, Bird, G. H., Ryan, J. A., Jenson, J. M., Godes, M., Pritz, J. R., Grant, R. A., Letai, A., Walensky, L. D., and Keating, A. E. (2018) Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc Natl Acad Sci U S A. 115, E886-E895
Fire, E., Gullá, S. V., Grant, R. A., and Keating, A. E. (2010) Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci. 19, 507-19
Wang, K. H., Román-Hernández, G., Grant, R. A., Sauer, R. T., and Baker, T. A. (2008) The molecular basis of N-end rule recognition. Mol Cell. 32, 406-14
Román-Hernández, G., Grant, R. A., Sauer, R. T., and Baker, T. A. (2009) Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc Natl Acad Sci U S A. 106, 8888-93
Bolon, D. N., Grant, R. A., Baker, T. A., and Sauer, R. T. (2004) Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell. 16, 343-50
Sohn, J., Grant, R. A., and Sauer, R. T. (2009) OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure. 17, 1411-21
Wang, B., Grant, R. A., and Laub, M. T. (2020) ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.. Mol Cell. 10.1016/j.molcel.2020.08.005
Bolon, D. N., Grant, R. A., Baker, T. A., and Sauer, R. T. (2005) Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A. 102, 12724-9
Hari, S. B., Grant, R. A., and Sauer, R. T. (2018) Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase.. Structure. 10.1016/j.str.2018.06.008
Wilker, E. W., Grant, R. A., Artim, S. C., and Yaffe, M. B. (2005) A structural basis for 14-3-3sigma functional specificity. J Biol Chem. 280, 18891-8
Stein, B. J., Grant, R. A., Sauer, R. T., and Baker, T. A. (2016) Structural Basis of an N-Degron Adaptor with More Stringent Specificity. Structure. 24, 232-42
Baytshtok, V., Fei, X., Grant, R. A., Baker, T. A., and Sauer, R. T. (2016) A Structurally Dynamic Region of the HslU Intermediate Domain Controls Protein Degradation and ATP Hydrolysis. Structure. 24, 1766-1777
Chien, P., Grant, R. A., Sauer, R. T., and Baker, T. A. (2007) Structure and substrate specificity of an SspB ortholog: design implications for AAA+ adaptors. Structure. 15, 1296-305

Pages