Publications

Found 8 results
Filters: Author is Kranzusch, Philip J  [Clear All Filters]
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Whiteley, A. T., Eaglesham, J. B., Mann, C. C. de Olive, Morehouse, B. R., Lowey, B., Nieminen, E. A., Danilchanka, O., King, D. S., S Y Lee, A., Mekalanos, J. J., and Kranzusch, P. J. (2019) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5
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Lowey, B., Whiteley, A. T., Keszei, A. F. A., Morehouse, B. R., Mathews, I. T., Antine, S. P., Cabrera, V. J., Kashin, D., Niemann, P., Jain, M., Schwede, F., Mekalanos, J. J., Shao, S., S Y Lee, A., and Kranzusch, P. J. (2020) CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 182, 38-49.e17
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Mann, C. C. de Olive, Orzalli, M. H., King, D. S., Kagan, J. C., S Y Lee, A., and Kranzusch, P. J. (2019) Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.. Cell Rep. 27, 1165-1175.e5
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Morehouse, B. R., Govande, A. A., Millman, A., Keszei, A. F. A., Lowey, B., Ofir, G., Shao, S., Sorek, R., and Kranzusch, P. J. (2020) STING cyclic dinucleotide sensing originated in bacteria. Nature. 10.1038/s41586-020-2719-5
Lau, R. K., Ye, Q., Birkholz, E. A., Berg, K. R., Patel, L., Mathews, I. T., Watrous, J. D., Ego, K., Whiteley, A. T., Lowey, B., Mekalanos, J. J., Kranzusch, P. J., Jain, M., Pogliano, J., and Corbett, K. D. (2020) Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 10.1016/j.molcel.2019.12.010
Zhou, W., Whiteley, A. T., Mann, C. C. de Olive, Morehouse, B. R., Nowak, R. P., Fischer, E. S., Gray, N. S., Mekalanos, J. J., and Kranzusch, P. J. (2018) Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 174, 300-311.e11
Eaglesham, J. B., McCarty, K. L., and Kranzusch, P. J. (2020) Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife. 10.7554/eLife.59753
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Eaglesham, J. B., Pan, Y., Kupper, T. S., and Kranzusch, P. J. (2019) Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 566, 259-263