Publications

Found 79 results
Filters: Author is Ealick, Steven E  [Clear All Filters]
2007
Kang, Y. - N., Tran, A., White, R. H., and Ealick, S. E. (2007) A novel function for the N-terminal nucleophile hydrolase fold demonstrated by the structure of an archaeal inosine monophosphate cyclohydrolase. Biochemistry. 46, 5050-62
Morar, M., White, R. H., and Ealick, S. E. (2007) Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids. Biochemistry. 46, 10562-71
Soriano, E. V., Clark, V. C., and Ealick, S. E. (2007) Structures of human deoxycytidine kinase product complexes. Acta Crystallogr D Biol Crystallogr. 63, 1201-7
2008
Zhang, Y., White, R. H., and Ealick, S. E. (2008) Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry. 47, 205-17
Jurgenson, C. T., Burns, K. E., Begley, T. P., and Ealick, S. E. (2008) Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry. 47, 10354-64
Morar, M., Hoskins, A. A., Stubbe, J. A., and Ealick, S. E. (2008) Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 47, 7816-30
Jenkins, A. L., Zhang, Y., Ealick, S. E., and Begley, T. P. (2008) Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorg Chem. 36, 29-32
Chatterjee, A., Li, Y., Zhang, Y., Grove, T. L., Lee, M., Krebs, C., Booker, S. J., Begley, T. P., and Ealick, S. E. (2008) Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nat Chem Biol. 4, 758-65
Bale, S., Lopez, M. M., Makhatadze, G. I., Fang, Q., Pegg, A. E., and Ealick, S. E. (2008) Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry. 47, 13404-17
Soriano, E. V., Rajashankar, K. R., Hanes, J. W., Bale, S., Begley, T. P., and Ealick, S. E. (2008) Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry. 47, 1346-57
McCulloch, K. M., Kinsland, C., Begley, T. P., and Ealick, S. E. (2008) Structural studies of thiamin monophosphate kinase in complex with substrates and products. Biochemistry. 47, 3810-21
2009
McCloskey, D. E., Bale, S., Secrist, J. A., Tiwari, A., Moss, T. H., Valiyaveettil, J., Brooks, W. H., Guida, W. C., Pegg, A. E., and Ealick, S. E. (2009) New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. J Med Chem. 52, 1388-407
Bale, S., Brooks, W., Hanes, J. W., Mahesan, A. M., Guida, W. C., and Ealick, S. E. (2009) Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 48, 6423-30
McCulloch, K. M., Mukherjee, T., Begley, T. P., and Ealick, S. E. (2009) Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry. 48, 4139-49
2010
French, J. B., and Ealick, S. E. (2010) Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry. 49, 5975-7
Mukherjee, T., Zhang, Y., Abdelwahed, S., Ealick, S. E., and Begley, T. P. (2010) Catalysis of a flavoenzyme-mediated amide hydrolysis. J Am Chem Soc. 132, 5550-1
Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E., and Ealick, S. E. (2010) Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 66, 181-9
Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E., and Lin, H. (2010) Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 465, 891-6
Paul, D., Chatterjee, A., Begley, T. P., and Ealick, S. E. (2010) Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes. Biochemistry. 49, 9922-34
Paul, D., O'Leary, S. E., Rajashankar, K., Bu, W., Toms, A., Settembre, E. C., Sanders, J. M., Begley, T. P., and Ealick, S. E. (2010) Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49, 3499-509
French, J. B., Cen, Y., Sauve, A. A., and Ealick, S. E. (2010) High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 49, 8803-12
Bale, S., Rajashankar, K. R., Perry, K., Begley, T. P., and Ealick, S. E. (2010) HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues. Biochemistry. 49, 8929-36
French, J. B., and Ealick, S. E. (2010) Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. J Biol Chem. 285, 35446-54
McCulloch, K. M., Mukherjee, T., Begley, T. P., and Ealick, S. E. (2010) Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase. Biochemistry. 49, 1226-35
2011
Seckute, J., McCloskey, D. E., H Thomas, J., Secrist, J. A., Pegg, A. E., and Ealick, S. E. (2011) Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Sci. 20, 1836-44

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