Publications

Found 592 results
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Journal Article
Gulati, S., Jastrzebska, B., Banerjee, S., Placeres, Á. L., Miszta, P., Gao, S., Gunderson, K., Tochtrop, G. P., Filipek, S., Katayama, K., Kiser, P. D., Mogi, M., Stewart, P. L., and Palczewski, K. (2017) Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 114, E2608-E2615
Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. - B., Seo, J. Ho, Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. - L., Jin, P., Alečković, M., LeRoy, G., Kang, Y., Sudderth, J. A., DeBerardinis, R. J., Luan, C. - H., Chen, G. Z., Muller, S., Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22, 585-600
Szewczyk, M. M., Ishikawa, Y., Organ, S., Sakai, N., Li, F., Halabelian, L., Ackloo, S., Couzens, A. L., Eram, M., Dilworth, D., Fukushi, H., Harding, R., Seña, C. C. Dela, Sugo, T., Hayashi, K., McLeod, D., Zepeda, C., Aman, A., Sánchez-Osuna, M., Bonneil, E., Takagi, S., Al-awar, R., Tyers, M., Richard, S., Takizawa, M., Gingras, A. - C., Arrowsmith, C. H., Vedadi, M., Brown, P. J., Nara, H., and Barsyte-Lovejoy, D. (2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun. 11, 2396
Reglero, C., Dieck, C. L., Zask, A., Forouhar, F., Laurent, A. P., Lin, W. - H. W., Albero, R., Miller, H. I., Ma, C., Gastier-Foster, J. M., Loh, M. L., Tong, L., Stockwell, B. R., Palomero, T., and Ferrando, A. A. (2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
Reglero, C., Dieck, C. L., Zask, A., Forouhar, F., Laurent, A. P., Lin, W. - H. W., Albero, R., Miller, H. I., Ma, C., Gastier-Foster, J. M., Loh, M. L., Tong, L., Stockwell, B. R., Palomero, T., and Ferrando, A. A. (2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
Feng, P., Wu, X., Erramilli, S. K., Paulo, J. A., Knejski, P., Gygi, S. P., Kossiakoff, A. A., and Rapoport, T. A. (2022) A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel. Nature. 607, 374-380
Tran, B., Pichling, P., Tenney, L., Connelly, C. M., Moon, M. H., Ferré-D'Amaré, A. R., Schneekloth, J. S., and Jones, C. P. (2020) Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chem Biol. 10.1016/j.chembiol.2020.07.021
Tao, Z., Fusco, A., Bin Huang, D. -, Gupta, K., Kim, D. Young, Ware, C. F., Van Duyne, G. D., and Ghosh, G. (2014) p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.. Proc Natl Acad Sci U S A. 111, 15946-51
Brugarolas, P., Movahedzadeh, F., Wang, Y., Zhang, N., Bartek, I. L., Gao, Y. N., Voskuil, M. I., Franzblau, S. G., and He, C. (2012) The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis. J Biol Chem. 287, 37703-12
Dong, M., Kathiresan, V., Fenwick, M. K., Torelli, A. T., Zhang, Y., Caranto, J. D., Dzikovski, B., Sharma, A., Lancaster, K. M., Freed, J. H., Ealick, S. E., Hoffman, B. M., and Lin, H. (2018) Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science. 359, 1247-1250
Dong, M., Kathiresan, V., Fenwick, M. K., Torelli, A. T., Zhang, Y., Caranto, J. D., Dzikovski, B., Sharma, A., Lancaster, K. M., Freed, J. H., Ealick, S. E., Hoffman, B. M., and Lin, H. (2018) Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science. 359, 1247-1250
Lee, K. Sing Steph, Liu, J. - Y., Wagner, K. M., Pakhomova, S., Dong, H., Morisseau, C., Fu, S. H., Yang, J., Wang, P., Ulu, A., Mate, C. A., Nguyen, L. V., Hwang, S. Hee, Edin, M. L., Mara, A. A., Wulff, H., Newcomer, M. E., Zeldin, D. C., and Hammock, B. D. (2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 57, 7016-30
Yang, Y., Liu, X. Roger, Greenberg, Z. J., Zhou, F., He, P., Fan, L., Liu, S., Shen, G., Egawa, T., Gross, M. L., Schuettpelz, L. G., and Li, W. (2020) Open conformation of tetraspanins shapes interaction partner networks on cell membranes. EMBO J. 39, e105246
Li, Y., Zhang, R., Wang, C., Forouhar, F., Clarke, O. B., Vorobiev, S., Singh, S., Montelione, G. T., Szyperski, T., Xu, Y., and Hunt, J. F. (2022) Oligomeric interactions maintain active-site structure in a noncooperative enzyme family. EMBO J. 10.15252/embj.2021108368
Pantel, L., Florin, T., Dobosz-Bartoszek, M., Racine, E., Sarciaux, M., Serri, M., Houard, J., Campagne, J. - M., de Figueiredo, R. Marcia, Midrier, C., Gaudriault, S., Givaudan, A., Lanois, A., Forst, S., Aumelas, A., Cotteaux-Lautard, C., Bolla, J. - M., Lundberg, C. Vingsbo, Huseby, D. L., Hughes, D., Villain-Guillot, P., Mankin, A. S., Polikanov, Y. S., and Gualtieri, M. (2018) Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol Cell. 70, 83-94.e7
Pantel, L., Florin, T., Dobosz-Bartoszek, M., Racine, E., Sarciaux, M., Serri, M., Houard, J., Campagne, J. - M., de Figueiredo, R. Marcia, Midrier, C., Gaudriault, S., Givaudan, A., Lanois, A., Forst, S., Aumelas, A., Cotteaux-Lautard, C., Bolla, J. - M., Lundberg, C. Vingsbo, Huseby, D. L., Hughes, D., Villain-Guillot, P., Mankin, A. S., Polikanov, Y. S., and Gualtieri, M. (2018) Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol Cell. 70, 83-94.e7
Morgan, J. L. W., McNamara, J. T., Fischer, M., Rich, J., Chen, H. - M., Withers, S. G., and Zimmer, J. (2016) Observing cellulose biosynthesis and membrane translocation in crystallo. Nature. 531, 329-34
Christ, B., Hochstrasser, R., Guyer, L., Francisco, R., Aubry, S., Hörtensteiner, S., and Weng, J. - K. (2017) Non-specific activities of the major herbicide-resistance gene BAR. Nat Plants. 3, 937-945
Kaiser, S. E., Mao, K., Taherbhoy, A. M., Yu, S., Olszewski, J. L., Duda, D. M., Kurinov, I., Deng, A., Fenn, T. D., Klionsky, D. J., and Schulman, B. A. (2012) Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nat Struct Mol Biol. 19, 1242-9
Fenwick, M. K., Mehta, A. P., Zhang, Y., Abdelwahed, S. H., Begley, T. P., and Ealick, S. E. (2015) Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nat Commun. 6, 6480
Kosciuk, T., Price, I. R., Zhang, X., Zhu, C., Johnson, K. N., Zhang, S., Halaby, S. L., Komaniecki, G. P., Yang, M., DeHart, C. J., Thomas, P. M., Kelleher, N. L., J Fromme, C., and Lin, H. (2020) NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 11, 1067
Zahid, H., Buchholz, C. R., Singh, M., Ciccone, M. F., Chan, A., Nithianantham, S., Shi, K., Aihara, H., Fischer, M., Schönbrunn, E., Santos, C. O. Dos, Landry, J. W., and Pomerantz, W. C. K. (2021) New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J Med Chem. 64, 13902-13917
Fenton, B. A., Tomberg, J., Sciandra, C. A., Nicholas, R. A., Davies, C., and Zhou, P. (2021) Mutations in PBP2 from Ceftriaxone-resistant Neisseria gonorrhoeae Alter the Dynamics of the β3-β4 Loop to Favor a Low-affinity Drug-binding State.. J Biol Chem. 10.1016/j.jbc.2021.101188
Welsch, M. E., Kaplan, A., Chambers, J. M., Stokes, M. E., Bos, P. H., Zask, A., Zhang, Y., Sanchez-Martin, M., Badgley, M. A., Huang, C. S., Tran, T. H., Akkiraju, H., Brown, L. M., Nandakumar, R., Cremers, S., Yang, W. Seok, Tong, L., Olive, K. P., Ferrando, A., and Stockwell, B. R. (2017) Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 168, 878-889.e29
Chang, Y., Sun, L., Kokura, K., Horton, J. R., Fukuda, M., Espejo, A., Izumi, V., Koomen, J. M., Bedford, M. T., Zhang, X., Shinkai, Y., Fang, J., and Cheng, X. (2011) MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun. 2, 533

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