Publications
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Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature. 530, 499-503
(2016) Structural basis of the XPB helicase-Bax1 nuclease complex interacting with the repair bubble DNA. Nucleic Acids Res. 48, 11695-11705
(2020) Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J Med Chem. 10.1021/acs.jmedchem.0c00200
(2020) Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS Med Chem Lett. 13, 1856-1863
(2022) Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. ACS Chem Biol. 10.1021/acschembio.0c00362
(2020) Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, A Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation. Biochemistry. 55, 3432-46
(2016) Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Biochemistry. 52, 477-87
(2013) Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme. Nature. 437, 838-44
(2005) (2015) Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase Aα.. Elife. 10.7554/eLife.44760
(2019) Structural and Functional Studies of Nucleoside Transporters. Ph.D. thesis, Duke University, Durham, North Carolina
(2017) Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening. Acta Crystallogr D Biol Crystallogr. 64, 941-9
(2008) Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry. 48, 9618-26
(2009) The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity.. Proc Natl Acad Sci U S A. 111, E1562-70
(2014) Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX. Nat Commun. 8, 1193
(2017) The structure and function of Mycobacterium tuberculosis MazF-mt6 toxin provide insights into conserved features of MazF endonucleases. J Biol Chem. 292, 7718-7726
(2017) Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing. Elife. 10.7554/eLife.51898
(2020) Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 55, 6545-6557
(2016) (2011) Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI. Sci Rep. 4, 4246
(2014) The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs. J Biol Chem. 10.1074/jbc.RA119.010188
(2019) Structures reveal opening of the store-operated calcium channel Orai. Elife. 10.7554/eLife.36758
(2018) Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 10.1021/acs.jmedchem.1c01180
(2021) Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor. J Mol Biol. 10.1016/j.jmb.2018.03.009
(2018) (2009)