Publications

Found 77 results
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Journal Article
French, J. B., Cen, Y., Sauve, A. A., and Ealick, S. E. (2010) High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 49, 8803-12
Paul, D., O'Leary, S. E., Rajashankar, K., Bu, W., Toms, A., Settembre, E. C., Sanders, J. M., Begley, T. P., and Ealick, S. E. (2010) Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49, 3499-509
Mukherjee, T., McCulloch, K. M., Ealick, S. E., and Begley, T. P. (2007) Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099. Biochemistry. 46, 13606-15
Eser, B. E., Zhang, X., Chanani, P. K., Begley, T. P., and Ealick, S. E. (2016) From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus jannaschii Thiamin Thiazole Biosynthesis. J Am Chem Soc. 138, 3639-42
Morar, M., Hoskins, A. A., Stubbe, J. A., and Ealick, S. E. (2008) Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry. 47, 7816-30
Toms, A. V., Kinsland, C., McCloskey, D. E., Pegg, A. E., and Ealick, S. E. (2004) Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. J Biol Chem. 279, 33837-46
Ye, W., Paul, D., Gao, L., Seckute, J., Sangaiah, R., Jayaraj, K., Zhang, Z., P Kaminski, A., Ealick, S. E., Gold, A., and Ball, L. M. (2014) Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites. PLoS One. 9, e115082
Paul, D., Chatterjee, A., Begley, T. P., and Ealick, S. E. (2010) Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes. Biochemistry. 49, 9922-34
Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E., and Lin, H. (2010) Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 465, 891-6
Fenwick, M. K., and Ealick, S. E. (2016) Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate. Biochemistry. 55, 4135-9
Tran, T. H., Christoffersen, S., Allan, P. W., Parker, W. B., Piskur, J., Serra, I., Terreni, M., and Ealick, S. E. (2011) The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases. Biochemistry. 50, 6549-58
Fenwick, M. K., Dong, M., Lin, H., and Ealick, S. E. (2019) The Crystal Structure of Dph2 in Complex with Elongation Factor 2 Reveals the Structural Basis for the First Step of Diphthamide Biosynthesis. Biochemistry. 58, 4343-4351
Zhang, Y., Dougherty, M., Downs, D. M., and Ealick, S. E. (2004) Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily. Structure. 12, 1809-21
Jurgenson, C. T., Burns, K. E., Begley, T. P., and Ealick, S. E. (2008) Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry. 47, 10354-64
Zhang, Y., Porcelli, M., Cacciapuoti, G., and Ealick, S. E. (2006) The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds. J Mol Biol. 357, 252-62
Zhang, Y., White, R. H., and Ealick, S. E. (2008) Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry. 47, 205-17
Sasaki, E., Zhang, X., Sun, H. G., Lu, M. -yehJade, Liu, T. -lin, Ou, A., Li, J. -yi, Chen, Y. -hsiang, Ealick, S. E., and Liu, H. -wen (2014) Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis. Nature. 510, 427-31
Bale, S., Baba, K., McCloskey, D. E., Pegg, A. E., and Ealick, S. E. (2010) Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 66, 181-9
Morar, M., Anand, R., Hoskins, A. A., Stubbe, J. A., and Ealick, S. E. (2006) Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry. 45, 14880-95
French, J. B., Neau, D. B., and Ealick, S. E. (2011) Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase. J Mol Biol. 410, 447-60
Mukherjee, T., Zhang, Y., Abdelwahed, S., Ealick, S. E., and Begley, T. P. (2010) Catalysis of a flavoenzyme-mediated amide hydrolysis. J Am Chem Soc. 132, 5550-1
Fenwick, M. K., Philmus, B., Begley, T. P., and Ealick, S. E. (2016) Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis. Biochemistry. 55, 2748-59
Fenwick, M. K., Almabruk, K. H., Ealick, S. E., Begley, T. P., and Philmus, B. (2017) Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase. Biochemistry. 10.1021/acs.biochem.7b00476
Hicks, K. A., and Ealick, S. E. (2016) Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway. Acta Crystallogr D Struct Biol. 72, 808-16
French, J. B., and Ealick, S. E. (2010) Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry. 49, 5975-7

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