Publications
Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.. Protein Sci. 20, 996-1004
(2011) Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer. Nat Commun. 5, 5726
(2014) Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens. Sci Transl Med. 15, eadf5668
(2023) The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun. 5, 2987
(2014) The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand. Curr Opin Struct Biol. 47, 30-39
(2017) Crystal structure of group II intron domain 1 reveals a template for RNA assembly. Nat Chem Biol. 11, 967-72
(2015) Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nat Struct Mol Biol. 23, 558-65
(2016) Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 10.1084/jem.20191792
(2020) (2008) (2017) Dramatic improvement of crystals of large RNAs by cation replacement and dehydration. Structure. 22, 1363-71
(2014) Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol. 8, 328-30
(2012) Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution. Acta Crystallogr D Biol Crystallogr. 62, 140-5
(2006) Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.. Biochemistry. 49, 10553-64
(2010) Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. Proc Natl Acad Sci U S A. 106, 9226-31
(2009) Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii. Biochemistry. 47, 205-17
(2008) Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases. Structure. 12, 1383-94
(2004) Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J Struct Biol. 192, 449-56
(2015) (2024) Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations. ACS Cent Sci. 7, 467-475
(2021) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature. 500, 363-6
(2013) Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J. 23, 2735-40
(2009) (2023) DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer. Proc Natl Acad Sci U S A. 119, e2216712119
(2022) Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 125, 2781-94
(2015)