Publications
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β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages.. Nat Struct Mol Biol. 18, 49-55
(2011) Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism.. Proc Natl Acad Sci U S A. 113, 4051-6
(2016) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
(2022) Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA. Cell Rep. 24, 453-462
(2018) Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv. 7, eabf4459
(2021) (2017) Functional and Structural Analysis of the Toxin-Binding Site of the Cadherin G-Protein-Coupled Receptor, BT-R, for Cry1A Toxins of . Biochemistry. 61, 752-766
(2022) Molecular and structural basis for Cγ-C bond formation by PLP-dependent enzyme Fub7.. Angew Chem Int Ed Engl. 10.1002/anie.202317161
(2024) Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Science. 10.1126/science.abc5667
(2020) Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell. 49, 719-29
(2013) (2018) Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.. Proc Natl Acad Sci U S A. 109, 20913-8
(2012) Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics.. J Am Chem Soc. 133, 6736-44
(2011) (2014) Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma. Sci Rep. 12, 12068
(2022) Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 10.1016/j.chembiol.2022.11.003
(2022) (2021) Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 13, 1891
(2022) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 429, 1829-1839
(2017) Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun. 4, 2495
(2013) Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer. Nat Commun. 5, 3110
(2014) Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. EMBO J. 26, 891-901
(2007) Computational design of a red fluorophore ligase for site-specific protein labeling in living cells. Proc Natl Acad Sci U S A. 111, E4551-9
(2014) Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer. J Mol Biol. 10.1016/j.jmb.2018.11.030
(2018) Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun. 14, 2338
(2023)