Publications
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Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs. Mol Cell. 59, 89-103
(2015) An engineered transforming growth factor β (TGF-β) monomer that functions as a dominant negative to block TGF-β signaling.. J Biol Chem. 292, 7173-7188
(2017) (2022) (2016) Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of alpha- and PPII-helices. Proc Natl Acad Sci U S A. 107, 5983-8
(2010) Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline. PLoS Pathog. 17, e1009965
(2021) Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One. 4, e6613
(2009) (2018) (2011) (2023) (2023) Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. 55, 6314-6326
(2016) The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 10.7554/eLife.45403
(2019) The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 10.7554/eLife.45403
(2019) Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Res. 49, 13179-13193
(2021) Dynamic bulge nucleotides in the KSHV PAN ENE triple helix provide a unique binding platform for small molecule ligands. Nucleic Acids Res. 49, 13179-13193
(2021) (2022) (2022) Duplex interrogation by a direct DNA repair protein in search of base damage. Nat Struct Mol Biol. 19, 671-6
(2012) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165, 1440-1453
(2016) A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev. 25, 137-52
(2011) Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. Nucleic Acids Res. 42, 8635-47
(2014) Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. J Biol Chem. 292, 12089-12099
(2017) (2021) (2020)