Publications

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Smith, C. R., Kulyk, S., Ahmad, M. Ud Din, Arkhipova, V., Christensen, J. G., Gunn, R. J., Ivetac, A., Ketcham, J. M., Kuehler, J., J Lawson, D., Thomas, N. C., Wang, X., and Marx, M. A. (2022) Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. RSC Med Chem. 13, 1549-1564
Smith, N. A., Clarke, O. B., Lee, M., Hodder, A. N., and Smith, B. J. (2020) Structure of the Plasmodium falciparum PfSERA5 pseudo-zymogen. Protein Sci. 29, 2245-2258
Sobolevsky, A. I., Rosconi, M. P., and Gouaux, E. (2009) X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 462, 745-56
Sohn, J., Grant, R. A., and Sauer, R. T. (2009) OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure. 17, 1411-21
Sohn, J., Grant, R. A., and Sauer, R. T. (2007) Allosteric activation of DegS, a stress sensor PDZ protease. Cell. 131, 572-83
Sohn, J., Grant, R. A., and Sauer, R. T. (2010) Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J Biol Chem. 285, 34039-47
Solano, Y. J., Everett, M. P., Dang, K. S., Abueg, J., and Kiser, P. D. (2024) Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore. Nat Chem Biol. 20, 779-788
Solmaz, S. R., Chauhan, R., Blobel, G., and Melčák, I. (2011) Molecular architecture of the transport channel of the nuclear pore complex. Cell. 147, 590-602
Son, J., Jang, J., Beyett, T. S., Eum, Y., Haikala, H. M., Verano, A., Lin, M., Hatcher, J. M., Kwiatkowski, N. P., Eser, P. Özden, Poitras, M. J., Wang, S., Xu, M., Gokhale, P. C., Cameron, M. D., Eck, M. J., Gray, N. S., and Jänne, P. A. (2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Res. 10.1158/0008-5472.CAN-21-2693
Song, J., Rechkoblit, O., Bestor, T. H., and Patel, D. J. (2011) Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 331, 1036-40
Song, X., Jensen, M. Ø., Jogini, V., Stein, R. A., Lee, C. - H., Mchaourab, H. S., Shaw, D. E., and Gouaux, E. (2018) Mechanism of NMDA receptor channel block by MK-801 and memantine. Nature. 10.1038/s41586-018-0039-9
Song, J., Teplova, M., Ishibe-Murakami, S., and Patel, D. J. (2012) Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science. 335, 709-12
Song, G., and Springer, T. A. (2014) Structures of the Toxoplasma gliding motility adhesin. Proc Natl Acad Sci U S A. 111, 4862-7
Song, W. Ju, Gucinski, G., Sazinsky, M. H., and Lippard, S. J. (2011) Tracking a defined route for O₂ migration in a dioxygen-activating diiron enzyme.. Proc Natl Acad Sci U S A. 108, 14795-800
Soragni, A., Yousefi, S., Stoeckle, C., Soriaga, A. B., Sawaya, M. R., Kozlowski, E., Schmid, I., Radonjic-Hoesli, S., Boutet, S., Williams, G. J., Messerschmidt, M., M Seibert, M., Cascio, D., Zatsepin, N. A., Burghammer, M., Riekel, C., Colletier, J. - P., Riek, R., Eisenberg, D. S., and Simon, H. - U. (2015) Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 57, 1011-21
Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Nguyen, A. Thai- Quynh, Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 29, 90-103
Soriaga, A. B., Sangwan, S., Macdonald, R., Sawaya, M. R., and Eisenberg, D. (2016) Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J Phys Chem B. 120, 5810-6
Soriano, E. V., Zhang, Y., Colabroy, K. L., Sanders, J. M., Settembre, E. C., Dorrestein, P. C., Begley, T. P., and Ealick, S. E. (2013) Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallogr D Biol Crystallogr. 69, 1685-96
Soriano, E. V., Rajashankar, K. R., Hanes, J. W., Bale, S., Begley, T. P., and Ealick, S. E. (2008) Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry. 47, 1346-57
Soriano, E. V., Clark, V. C., and Ealick, S. E. (2007) Structures of human deoxycytidine kinase product complexes. Acta Crystallogr D Biol Crystallogr. 63, 1201-7
Sosa, B. A., Rothballer, A., Kutay, U., and Schwartz, T. U. (2012) LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins. Cell. 149, 1035-47
Sosa, B. A., F Demircioglu, E., Chen, J. Z., Ingram, J., Ploegh, H. L., and Schwartz, T. U. (2014) How lamina-associated polypeptide 1 (LAP1) activates Torsin. Elife. 3, e03239
Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2010) Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66, 85-100
Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2012) Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492, 128-32
Soule, J., Gnann, A. D., Gonzalez, R., Parker, M. J., McKenna, K. C., Nguyen, S. V., Phan, N. T., Wicht, D. K., and Dowling, D. P. (2019) Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation. Biochem Biophys Res Commun. 10.1016/j.bbrc.2019.11.008

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