Publications
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(2024)
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem. 64, 10849-10877
(2021) HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun. 9, 1111
(2018) HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions. JCI Insight. 10.1172/jci.insight.131437
(2020) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 13, 1195-1201
(2017) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 13, 1195-1201
(2017) How ATP and dATP Act as Molecular Switches to Regulate Enzymatic Activity in the Prototypical Bacterial Class Ia Ribonucleotide Reductase. Biochemistry. 63, 2517-2531
(2024) Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors. Protein Sci. 26, 242-257
(2017) Identification and structural characterization of small molecule inhibitors of PINK1. Sci Rep. 14, 7739
(2024) Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain. J Mol Biol. 431, 885-903
(2019) Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase. Biochemistry. 49, 5035-41
(2010) Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol Cell. 53, 140-7
(2014) (2020) Identification of , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.. J Med Chem. 10.1021/acs.jmedchem.2c00998
(2022) Identification of , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.. J Med Chem. 10.1021/acs.jmedchem.2c00998
(2022) Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics. ACS Med Chem Lett. 12, 1824-1831
(2021) Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor. J Med Chem. 10.1021/acs.jmedchem.1c01688
(2021) Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor. J Med Chem. 10.1021/acs.jmedchem.1c01688
(2021) Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat Struct Mol Biol. 29, 529-536
(2022) Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. 28, 946-957
(2022) Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Mol Ther. 10.1016/j.ymthe.2018.12.010
(2018) Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc Natl Acad Sci U S A. 120, e2214556120
(2023) Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 120, e2222073120
(2023) Indoline CD4-mimetic compounds mediate potent and broad HIV-1 inhibition and sensitization to antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 120, e2222073120
(2023) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 22, 1465-1469
(2016)