Structural work on SARS-CoV-2 papain-like protease, SARS-CoV-2-PLpro, required for processing viral polyproteins to generate a functional replicase complex and enable viral spread has been featured as a highlight on the APS website.

Work on SARS-CoV-2 RNA capping by the lab of Yogesh Gupta using NE-CAT and previously published at BioRxiv has now been published at Nature Communications, featured on the Science Board website and is also a highlight on the APS website

SARS-CoV-2 is a zoonotic virus that has caused a pandemic of severe respiratory disease—COVID-19— within several months of its initial identification. Comparable to the first SARS-CoV, this novel coronavirus’s surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and, thus, is the principal target for the development of vaccines and immunotherapeutics.