Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.

Publication Type:

Journal Article


Nat Struct Mol Biol, Volume 15, Issue 4, p.422-3 (2008)


Crystallography, X-Ray, Humans, Models, Molecular, Protein Binding, Protein Conformation, Receptors, Cell Surface, Receptors, Urokinase Plasminogen Activator, Urokinase-Type Plasminogen Activator, Vitronectin


<p>The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.</p>