Publications

Found 505 results
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2020
Zhao, H., Xu, L., Bombardi, R., Nargi, R., Deng, Z., Errico, J. M., Nelson, C. A., Dowd, K. A., Pierson, T. C., Crowe, J. E., Diamond, M. S., and Fremont, D. H. (2020) Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 10.1084/jem.20191792
Yang, Y., Liu, X. Roger, Greenberg, Z. J., Zhou, F., He, P., Fan, L., Liu, S., Shen, G., Egawa, T., Gross, M. L., Schuettpelz, L. G., and Li, W. (2020) Open conformation of tetraspanins shapes interaction partner networks on cell membranes. EMBO J. 39, e105246
Szewczyk, M. M., Ishikawa, Y., Organ, S., Sakai, N., Li, F., Halabelian, L., Ackloo, S., Couzens, A. L., Eram, M., Dilworth, D., Fukushi, H., Harding, R., Seña, C. C. Dela, Sugo, T., Hayashi, K., McLeod, D., Zepeda, C., Aman, A., Sánchez-Osuna, M., Bonneil, E., Takagi, S., Al-awar, R., Tyers, M., Richard, S., Takizawa, M., Gingras, A. - C., Arrowsmith, C. H., Vedadi, M., Brown, P. J., Nara, H., and Barsyte-Lovejoy, D. (2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun. 11, 2396
Dussupt, V., Sankhala, R. S., Gromowski, G. D., Donofrio, G., De La Barrera, R. A., Larocca, R. A., Zaky, W., Mendez-Rivera, L., Choe, M., Davidson, E., McCracken, M. K., Brien, J. D., Abbink, P., Bai, H., Bryan, A. L., Bias, C. Hope, Berry, I. Maljkovic, Botero, N., Cook, T., Doria-Rose, N. A., Escuer, A. Grinyo I., Frimpong, J. Akuoku, Geretz, A., Hernandez, M., Hollidge, B. S., Jian, N., Kabra, K., Leggat, D. J., Liu, J., Pinto, A. K., Rutvisuttinunt, W., Setliff, I., Tran, U., Townsley, S., Doranz, B. J., Rolland, M., McDermott, A. B., Georgiev, I. S., Thomas, R., Robb, M. L., Eckels, K. H., Barranco, E., Koren, M., Smith, D. R., Jarman, R. G., George, S. L., Stephenson, K. E., Barouch, D. H., Modjarrad, K., Michael, N. L., M Joyce, G., and Krebs, S. J. (2020) Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 26, 228-235
Dussupt, V., Sankhala, R. S., Gromowski, G. D., Donofrio, G., De La Barrera, R. A., Larocca, R. A., Zaky, W., Mendez-Rivera, L., Choe, M., Davidson, E., McCracken, M. K., Brien, J. D., Abbink, P., Bai, H., Bryan, A. L., Bias, C. Hope, Berry, I. Maljkovic, Botero, N., Cook, T., Doria-Rose, N. A., Escuer, A. Grinyo I., Frimpong, J. Akuoku, Geretz, A., Hernandez, M., Hollidge, B. S., Jian, N., Kabra, K., Leggat, D. J., Liu, J., Pinto, A. K., Rutvisuttinunt, W., Setliff, I., Tran, U., Townsley, S., Doranz, B. J., Rolland, M., McDermott, A. B., Georgiev, I. S., Thomas, R., Robb, M. L., Eckels, K. H., Barranco, E., Koren, M., Smith, D. R., Jarman, R. G., George, S. L., Stephenson, K. E., Barouch, D. H., Modjarrad, K., Michael, N. L., M Joyce, G., and Krebs, S. J. (2020) Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 26, 228-235
Pomerantz, W. Charles Kr, Cui, H., Divakaran, A., Pandey, A. K., Johnson, J. A., Zahid, H., Hoell, Z. J., Ellingson, M. O., Shi, K., Aihara, H., and Harki, D. A. (2020) Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement. Angew Chem Int Ed Engl. 10.1002/anie.202008625
Rizzolo, K., Weitz, A. C., Cohen, S. E., Drennan, C. L., Hendrich, M. P., and Elliott, S. J. (2020) A Stable Ferryl Porphyrin at the Active Site of Y463M BthA. J Am Chem Soc. 142, 11978-11982
Heppner, D. E., Günther, M., Wittlinger, F., Laufer, S. A., and Eck, M. J. (2020) Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J Med Chem. 10.1021/acs.jmedchem.0c00200
Kwon, Y., Kaake, R. M., Echeverria, I., Suarez, M., Shamsabadi, M. Karimian, Stoneham, C., Ramirez, P. W., Kress, J., Singh, R., Sali, A., Krogan, N., Guatelli, J., and Jia, X. (2020) Structural basis of CD4 downregulation by HIV-1 Nef. Nat Struct Mol Biol. 10.1038/s41594-020-0463-z
Fenwick, M. K., and Ealick, S. E. (2020) Structural basis of elongation factor 2 switching. Curr Res Struct Biol. 2, 25-34
Fenwick, M. K., Su, D., Dong, M., Lin, H., and Ealick, S. E. (2020) Structural Basis of the Substrate Selectivity of Viperin. Biochemistry. 10.1021/acs.biochem.9b00741
Faust, T. B., Yoon, H., Nowak, R. P., Donovan, K. A., Li, Z., Cai, Q., Eleuteri, N. A., Zhang, T., Gray, N. S., and Fischer, E. S. (2020) Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol. 16, 7-14
Edani, B. H., Grabińska, K. A., Zhang, R., Park, E. Joo, Siciliano, B., Surmacz, L., Ha, Y., and Sessa, W. C. (2020) Structural elucidation of the -prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation. Proc Natl Acad Sci U S A. 10.1073/pnas.2008381117
Yan, W., Markegard, E., Dharmaiah, S., Urisman, A., Drew, M., Esposito, D., Scheffzek, K., Nissley, D. V., McCormick, F., and Simanshu, D. K. (2020) Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 32, 107909
Lau, R. K., Ye, Q., Birkholz, E. A., Berg, K. R., Patel, L., Mathews, I. T., Watrous, J. D., Ego, K., Whiteley, A. T., Lowey, B., Mekalanos, J. J., Kranzusch, P. J., Jain, M., Pogliano, J., and Corbett, K. D. (2020) Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 10.1016/j.molcel.2019.12.010
Basu, R., Eichhorn, C. D., Cheng, R., Peterson, R. D., and Feigon, J. (2020) Structure of telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins. RNA Biol. 10.1080/15476286.2020.1836891
Jia, N., Xie, W., M de la Cruz, J., Eng, E. T., and Patel, D. J. (2020) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Res. 10.1038/s41422-019-0272-2
Eaglesham, J. B., McCarty, K. L., and Kranzusch, P. J. (2020) Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife. 10.7554/eLife.59753
Kwak, S. - H., C Cochrane, S., Ennis, A. F., Lim, W. Young, Webster, C. G., Cho, J., Fenton, B. A., Zhou, P., and Hong, J. (2020) Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. Bioorg Chem. 102, 104055
Mukherjee, S., Erramilli, S. K., Ammirati, M., Alvarez, F. J. D., Fennell, K. F., Purdy, M. D., Skrobek, B. M., Radziwon, K., Coukos, J., Kang, Y., Dutka, P., Gao, X., Qiu, X., Yeager, M., H Xu, E., Han, S., and Kossiakoff, A. A. (2020) Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun. 11, 1598
Koirala, S., Klein, J., Zheng, Y., Glenn, N. O., Eisemann, T., Tacer, K. Fon, Miller, D. J., Kulak, O., Lu, M., Finkelstein, D. B., Neale, G., Tillman, H., Vogel, P., Strand, D. W., Lum, L., Brautigam, C. A., Pascal, J. M., Clements, W. K., and Potts, P. Ryan (2020) Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.. Cell Rep. 32, 107922
2019
Ejaz, A., Goldgur, Y., and Shuman, S. (2019) Activity and structure of MPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster. J Biol Chem. 10.1074/jbc.RA119.008049
Park, E., Rawson, S., Li, K., Kim, B. - W., Ficarro, S. B., Del Pino, G. Gonzalez-, Sharif, H., Marto, J. A., Jeon, H., and Eck, M. J. (2019) Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. 575, 545-550
G Hobbs, A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., J Diehl, N., Papke, B., Hodge, R. G., Klomp, J. E., Goodwin, C. M., DeLiberty, J. M., Wang, J., Ng, R. W. S., Gautam, P., Bryant, K. L., Esposito, D., Campbell, S. L., Petricoin, E. F., Simanshu, D. K., Aguirre, A. J., Wolpin, B. M., Wennerberg, K., Rudloff, U., Cox, A. D., and Der, C. J. (2019) Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov. 10.1158/2159-8290.CD-19-1006
Whiteley, A. T., Eaglesham, J. B., Mann, C. C. de Olive, Morehouse, B. R., Lowey, B., Nieminen, E. A., Danilchanka, O., King, D. S., S Y Lee, A., Mekalanos, J. J., and Kranzusch, P. J. (2019) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5

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