Publications
(2016) Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Res. 26, 901-13
(2016) X-ray structures define human P2X(3) receptor gating cycle and antagonist action. Nature. 538, 66-71
(2016) γ-Protocadherin structural diversity and functional implications.. Elife. 10.7554/eLife.20930
(2015) 13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase. J Biol Chem. 290, 7897-909
(2015) Action at a distance: mutations of peripheral residues transform rapid reversible inhibitors to slow, tight binders of cyclooxygenase-2. J Biol Chem. 290, 12793-803
(2015) An ancient protein-DNA interaction underlying metazoan sex determination. Nat Struct Mol Biol. 22, 442-51
(2015) Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 11, 409-15
(2015) Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 348, 1155-60
(2015) Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell. 160, 219-27
(2015) Conformational Changes of the Clamp of the Protein Translocation ATPase SecA. J Mol Biol. 427, 2348-59
(2015) Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit.. J Biol Chem. 290, 14328-37
(2015) Crystallization of proteins from crude bovine rod outer segments. Methods Enzymol. 557, 439-58
(2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 25, 4824-4827
(2015) EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat Struct Mol Biol. 22, 983-90
(2015) Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. RNA. 21, 1135-46
(2015) Heterogeneity of functional groups in a metal-organic framework displays magic number ratios. Proc Natl Acad Sci U S A. 112, 5591-6
(2015) Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 59, 970-83
(2015) Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 59, 970-83
(2015) Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol Cell. 59, 970-83
(2015) Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3. J Biol Chem. 290, 30018-29
(2015) Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3. J Biol Chem. 290, 30018-29