Publications

Found 575 results
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2017
Chan, A. H., Lee, W. - G., Spasov, K. A., Cisneros, J. A., Kudalkar, S. N., Petrova, Z. O., Buckingham, A. B., Anderson, K. S., and Jorgensen, W. L. (2017) Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proc Natl Acad Sci U S A. 10.1073/pnas.1711463114
Padayatti, P. S., Leung, J. H., Mahinthichaichan, P., Tajkhorshid, E., Ishchenko, A., Cherezov, V., S Soltis, M., J Jackson, B., C Stout, D., Gennis, R. B., and Zhang, Q. (2017) Critical Role of Water Molecules in Proton Translocation by the Membrane-Bound Transhydrogenase. Structure. 25, 1111-1119.e3
Liu, Y., Pan, J., Jenni, S., Raymond, D. D., Caradonna, T., Do, K. T., Schmidt, A. G., Harrison, S. C., and Grigorieff, N. (2017) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 429, 1829-1839
Vaidya, A. T., Lomakin, I. B., Joseph, N. N., Dmitriev, S. E., and Steitz, T. A. (2017) Crystal Structure of the C-terminal Domain of Human eIF2D and its Implications on Eukaryotic Translation Initiation. J Mol Biol. 10.1016/j.jmb.2017.07.015
Yao, G., Lam, K. - H., Perry, K., Weisemann, J., Rummel, A., and Jin, R. (2017) Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel). 10.3390/toxins9030093
Barnash, K. D., The, J., Norris-Drouin, J. L., Cholensky, S. H., Worley, B. M., Li, F., Stuckey, J. I., Brown, P. J., Vedadi, M., Arrowsmith, C. H., Frye, S. V., and James, L. I. (2017) Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS Comb Sci. 19, 161-172
Xiong, Y., Li, F., Babault, N., Dong, A., Zeng, H., Wu, H., Chen, X., Arrowsmith, C. H., Brown, P. J., Liu, J., Vedadi, M., and Jin, J. (2017) Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J Med Chem. 60, 1876-1891
Jenson, J. M., Ryan, J. A., Grant, R. A., Letai, A., and Keating, A. E. (2017) Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife. 10.7554/eLife.25541
McGee, J. H., Shim, S. Youn, Lee, S. - J., Swanson, P. K., Jiang, Y., Durney, M. A., and Verdine, G. L. (2017) Exceptionally high-affinity Ras binders that remodel its effector domain. J Biol Chem. 10.1074/jbc.M117.816348
Moremen, K. W., Ramiah, A., Stuart, M., Steel, J., Meng, L., Forouhar, F., Moniz, H. A., Gahlay, G., Gao, Z., Chapla, D., Wang, S., Yang, J. - Y., Prabhakar, P. Kumar, Johnson, R., Rosa, M. Dela, Geisler, C., Nairn, A. V., Seetharaman, J., Wu, S. - C., Tong, L., Gilbert, H. J., LaBaer, J., and Jarvis, D. L. (2017) Expression system for structural and functional studies of human glycosylation enzymes. Nat Chem Biol. 10.1038/nchembio.2539
Moremen, K. W., Ramiah, A., Stuart, M., Steel, J., Meng, L., Forouhar, F., Moniz, H. A., Gahlay, G., Gao, Z., Chapla, D., Wang, S., Yang, J. - Y., Prabhakar, P. Kumar, Johnson, R., Rosa, M. Dela, Geisler, C., Nairn, A. V., Seetharaman, J., Wu, S. - C., Tong, L., Gilbert, H. J., LaBaer, J., and Jarvis, D. L. (2017) Expression system for structural and functional studies of human glycosylation enzymes. Nat Chem Biol. 10.1038/nchembio.2539
Warner, K. Deigan, Sjekloća, L., Song, W., Filonov, G. S., Jaffrey, S. R., and Ferré-D'Amaré, A. R. (2017) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 13, 1195-1201
Clark, K. M., Jenkins, J. L., Fedoriw, N., and Dumont, M. E. (2017) Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors. Protein Sci. 26, 242-257
Lam, K. - H., Qi, R., Liu, S., Kroh, A., Yao, G., Perry, K., Rummel, A., and Jin, R. (2017) The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon. 10.1016/j.toxicon.2017.10.012
Puleo, D. E., Kucera, K., Hammarén, H. M., Ungureanu, D., Newton, A. S., Silvennoinen, O., Jorgensen, W. L., and Schlessinger, J. (2017) Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett. 8, 618-621
Newton, A. S., Deiana, L., Puleo, D. E., Cisneros, J. A., Cutrona, K. J., Schlessinger, J., and Jorgensen, W. L. (2017) JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 8, 614-617
Chevalier, A., Silva, D. - A., Rocklin, G. J., Hicks, D. R., Vergara, R., Murapa, P., Bernard, S. M., Zhang, L., Lam, K. - H., Yao, G., Bahl, C. D., Miyashita, S. - I., Goreshnik, I., Fuller, J. T., Koday, M. T., Jenkins, C. M., Colvin, T., Carter, L., Bohn, A., Bryan, C. M., D Fernández-Velasco, A., Stewart, L., Dong, M., Huang, X., Jin, R., Wilson, I. A., Fuller, D. H., and Baker, D. (2017) Massively parallel de novo protein design for targeted therapeutics. Nature. 550, 74-79
Chevalier, A., Silva, D. - A., Rocklin, G. J., Hicks, D. R., Vergara, R., Murapa, P., Bernard, S. M., Zhang, L., Lam, K. - H., Yao, G., Bahl, C. D., Miyashita, S. - I., Goreshnik, I., Fuller, J. T., Koday, M. T., Jenkins, C. M., Colvin, T., Carter, L., Bohn, A., Bryan, C. M., D Fernández-Velasco, A., Stewart, L., Dong, M., Huang, X., Jin, R., Wilson, I. A., Fuller, D. H., and Baker, D. (2017) Massively parallel de novo protein design for targeted therapeutics. Nature. 550, 74-79
Yockey, O. P., Jha, V., Ghodke, P. P., Xu, T., Xu, W., Ling, H., Pradeepkumar, P. I., and Zhao, L. (2017) Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase κ.. Chem Res Toxicol. 10.1021/acs.chemrestox.7b00227
Jain, R., Choudhury, J. Roy, Buku, A., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2017) Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.. Sci Rep. 7, 43904
Jain, R., Choudhury, J. Roy, Buku, A., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2017) Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.. Sci Rep. 7, 43904
Yang, H., Jiang, X., Li, B., Yang, H. J., Miller, M., Yang, A., Dhar, A., and Pavletich, N. P. (2017) Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature. 552, 368-373
Huang, H. - T., Seo, H. - S., Zhang, T., Wang, Y., Jiang, B., Li, Q., Buckley, D. L., Nabet, B., Roberts, J. M., Paulk, J., Dastjerdi, S., Winter, G. E., McLauchlan, H., Moran, J., Bradner, J. E., Eck, M. J., Dhe-Paganon, S., Zhao, J. J., and Gray, N. S. (2017) MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 10.7554/eLife.26693
Zhang, Y., Shan, C. - M., Wang, J., Bao, K., Tong, L., and Jia, S. (2017) Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Sci Rep. 7, 43906
Gulati, S., Jastrzebska, B., Banerjee, S., Placeres, Á. L., Miszta, P., Gao, S., Gunderson, K., Tochtrop, G. P., Filipek, S., Katayama, K., Kiser, P. D., Mogi, M., Stewart, P. L., and Palczewski, K. (2017) Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 114, E2608-E2615

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