Structural basis for exon recognition by a group II intron.

Publication Type:

Journal Article

Authors:

Toor, Navtej; Rajashankar, Kanagalaghatta; Keating, Kevin S; Pyle, Anna Marie

Source:

Nat Struct Mol Biol, Volume 15, Issue 11, p.1221-2 (2008)

Keywords:

Crystallography, X-Ray, Exons, Introns, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation

Abstract:

<p>Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.</p>