A structure-based kinetic model of transcription.
Publication Type:Journal Article
Source:Transcription, Volume 8, Issue 1, p.1-8 (2017)
Keywords:DNA, DNA-Directed RNA Polymerases, Models, Molecular, Transcription, Genetic
<p>During transcription, RNA polymerase moves downstream along the DNA template and maintains a transcription bubble. Several recent structural studies of transcription complexes with a complete transcription bubble provide new insights into how RNAP couples the nucleotide addition reaction to its directional movement.</p>