Publications

Found 594 results
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2017
Ren, X., Gelinas, A. D., von Carlowitz, I., Janjic, N., and Pyle, A. Marie (2017) Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.. Nat Commun. 8, 810
Seegar, T. C. M., Killingsworth, L. B., Saha, N., Meyer, P. A., Patra, D., Zimmerman, B., Janes, P. W., Rubinstein, E., Nikolov, D. B., Skiniotis, G., Kruse, A. C., and Blacklow, S. C. (2017) Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.. Cell. 171, 1638-1648.e7
Ejaz, A., Ordonez, H., Jacewicz, A., Ferrao, R., and Shuman, S. (2017) Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res. 10.1093/nar/gkx1163
Xiong, Y., Li, F., Babault, N., Wu, H., Dong, A., Zeng, H., Chen, X., Arrowsmith, C. H., Brown, P. J., Liu, J., Vedadi, M., and Jin, J. (2017) Structure-activity relationship studies of G9a-like protein (GLP) inhibitors. Bioorg Med Chem. 25, 4414-4423
Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D. J., and Wang, Y. (2017) Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res. 45, 9149-9163
Hirschi, M., Johnson, Z. Lee, and Lee, S. - Y. (2017) Visualizing multistep elevator-like transitions of a nucleoside transporter. Nature. 545, 66-70
2016
Atapattu, L., Saha, N., Chheang, C., Eissman, M. F., Xu, K., Vail, M. E., Hii, L., Llerena, C., Liu, Z., Horvay, K., Abud, H. E., Kusebauch, U., Moritz, R. L., Ding, B. - S., Cao, Z., Rafii, S., Ernst, M., Scott, A. M., Nikolov, D. B., Lackmann, M., and Janes, P. W. (2016) An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med. 213, 1741-57
Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. - I., Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., J Fromme, C., K Garcia, C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. José Barb, Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M., and Sliz, P. (2016) Data publication with the structural biology data grid supports live analysis. Nat Commun. 7, 10882
Lee, W. - G., Chan, A. H., Spasov, K. A., Anderson, K. S., and Jorgensen, W. L. (2016) Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. ACS Med Chem Lett. 7, 1156-1160
Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Nguyen, A. Thai- Quynh, Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 29, 90-103
Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Nguyen, A. Thai- Quynh, Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 29, 90-103
Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Nguyen, A. Thai- Quynh, Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 29, 90-103
Choi, P. H., Jo, J., Lin, Y. - C., Lin, M. - H., Chou, C. - Y., Dietrich, L. E. P., and Tong, L. (2016) A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun. 7, 12713
Hancock, S. P., Stella, S., Cascio, D., and Johnson, R. C. (2016) DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis. PLoS One. 11, e0150189
Brown, N. G., VanderLinden, R., Watson, E. R., Weissmann, F., Ordureau, A., Wu, K. - P., Zhang, W., Yu, S., Mercredi, P. Y., Harrison, J. S., Davidson, I. F., Qiao, R., Lu, Y., Dube, P., Brunner, M. R., Grace, C. R. R., Miller, D. J., Haselbach, D., Jarvis, M. A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S. S., Kuhlman, B., Kirschner, M. W., J Harper, W., Peters, J. - M., Stark, H., and Schulman, B. A. (2016) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165, 1440-1453
McMillan, B. J., Tibbe, C., Jeon, H., Drabek, A. A., Klein, T., and Blacklow, S. C. (2016) Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein. Cell Rep. 16, 1211-1217
Shan, C. - M., Wang, J., Xu, K., Chen, H., Yue, J. - X., Andrews, S., Moresco, J. J., Yates, J. R., Nagy, P. L., Tong, L., and Jia, S. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Elife. 10.7554/eLife.17903
Goodman, K. M., Yamagata, M., Jin, X., Mannepalli, S., Katsamba, P. S., Ahlsen, G., Sergeeva, A. P., Honig, B., Sanes, J. R., and Shapiro, L. (2016) Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife. 10.7554/eLife.19058
Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S. - H., Kim, B., R Mavioglu, N., Tolun, A., Jipa, A., Takats, S., Karpati, M., Li, J. Z., Yapici, Z., Juhasz, G., Lee, J. Hee, Klionsky, D. J., and Burmeister, M. (2016) Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. Elife. 10.7554/eLife.12245
Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S. - H., Kim, B., R Mavioglu, N., Tolun, A., Jipa, A., Takats, S., Karpati, M., Li, J. Z., Yapici, Z., Juhasz, G., Lee, J. Hee, Klionsky, D. J., and Burmeister, M. (2016) Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. Elife. 10.7554/eLife.12245
Lim, D. Young, Shin, S. Ho, Lee, M. - H., Malakhova, M., Kurinov, I., Wu, Q., Xu, J., Jiang, Y., Dong, Z., Liu, K., Lee, K. Yeong, Bae, K. Beom, Choi, B. Young, Deng, Y., Bode, A., and Dong, Z. (2016) A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. Oncotarget. 7, 35001-14
Yao, G., Zhang, S., Mahrhold, S., Lam, K. - H., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., and Jin, R. (2016) N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 23, 656-62
Gibson, M. I., Chen, P. Yang- Ting, Johnson, A. C., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2016) One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography. Proc Natl Acad Sci U S A. 113, 320-5
Eram, M. S., Shen, Y., Szewczyk, M., Wu, H., Senisterra, G., Li, F., Butler, K. V., H Kaniskan, Ü., Speed, B. A., Seña, Cdela, Dong, A., Zeng, H., Schapira, M., Brown, P. J., Arrowsmith, C. H., Barsyte-Lovejoy, D., Liu, J., Vedadi, M., and Jin, J. (2016) A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 11, 772-781
Hill, M. E., MacPherson, D. J., Wu, P., Julien, O., Wells, J. A., and Hardy, J. A. (2016) Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 11, 1603-12

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