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2016

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81

Brown, N. G., VanderLinden, R., Watson, E. R., Weissmann, F., Ordureau, A., Wu, K. - P., Zhang, W., Yu, S., Mercredi, P. Y., Harrison, J. S., Davidson, I. F., Qiao, R., Lu, Y., Dube, P., Brunner, M. R., Grace, C. R. R., Miller, D. J., Haselbach, D., Jarvis, M. A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S. S., Kuhlman, B., Kirschner, M. W., J Harper, W., Peters, J. - M., Stark, H., and Schulman, B. A. (2016) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165, 1440-1453

Brown, N. G., VanderLinden, R., Watson, E. R., Weissmann, F., Ordureau, A., Wu, K. - P., Zhang, W., Yu, S., Mercredi, P. Y., Harrison, J. S., Davidson, I. F., Qiao, R., Lu, Y., Dube, P., Brunner, M. R., Grace, C. R. R., Miller, D. J., Haselbach, D., Jarvis, M. A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S. S., Kuhlman, B., Kirschner, M. W., J Harper, W., Peters, J. - M., Stark, H., and Schulman, B. A. (2016) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165, 1440-1453

Brown, N. G., VanderLinden, R., Watson, E. R., Weissmann, F., Ordureau, A., Wu, K. - P., Zhang, W., Yu, S., Mercredi, P. Y., Harrison, J. S., Davidson, I. F., Qiao, R., Lu, Y., Dube, P., Brunner, M. R., Grace, C. R. R., Miller, D. J., Haselbach, D., Jarvis, M. A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S. S., Kuhlman, B., Kirschner, M. W., J Harper, W., Peters, J. - M., Stark, H., and Schulman, B. A. (2016) Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 165, 1440-1453

Levsh, O., Chiang, Y. - C., Tung, C. Fai, Noel, J. P., Wang, Y., and Weng, J. - K. (2016) Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. 55, 6314-6326

Levsh, O., Chiang, Y. - C., Tung, C. Fai, Noel, J. P., Wang, Y., and Weng, J. - K. (2016) Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. 55, 6314-6326

Dhayalan, B., Fitzpatrick, A., Mandal, K., Whittaker, J., Weiss, M. A., Tokmakoff, A., and Kent, S. B. H. (2016) Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR. Chembiochem. 17, 415-20

Dhayalan, B., Fitzpatrick, A., Mandal, K., Whittaker, J., Weiss, M. A., Tokmakoff, A., and Kent, S. B. H. (2016) Efficient Total Chemical Synthesis of (13) C=(18) O Isotopomers of Human Insulin for Isotope-Edited FTIR. Chembiochem. 17, 415-20

Shan, C. - M., Wang, J., Xu, K., Chen, H., Yue, J. - X., Andrews, S., Moresco, J. J., Yates, J. R., Nagy, P. L., Tong, L., and Jia, S. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Elife. 10.7554/eLife.17903

Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weïwer, M., W An, F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. - L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. - L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63

Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weïwer, M., W An, F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. - L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. - L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63

Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weïwer, M., W An, F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. - L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. - L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63

Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weïwer, M., W An, F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. - L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. - L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63

Wong, S. J., Gearhart, M. D., Taylor, A. B., Nanyes, D. R., Ha, D. J., Robinson, A. K., Artigas, J. A., Lee, O. J., Demeler, B., P Hart, J., Bardwell, V. J., and Kim, C. A. (2016) KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Structure. 24, 1795-1801

Baskin, J. M., Wu, X., Christiano, R., Oh, M. S., Schauder, C. M., Gazzerro, E., Messa, M., Baldassari, S., Assereto, S., Biancheri, R., Zara, F., Minetti, C., Raimondi, A., Simons, M., Walther, T. C., Reinisch, K. M., and De Camilli, P. (2016) The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.. Nat Cell Biol. 18, 132-8

Baskin, J. M., Wu, X., Christiano, R., Oh, M. S., Schauder, C. M., Gazzerro, E., Messa, M., Baldassari, S., Assereto, S., Biancheri, R., Zara, F., Minetti, C., Raimondi, A., Simons, M., Walther, T. C., Reinisch, K. M., and De Camilli, P. (2016) The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.. Nat Cell Biol. 18, 132-8

Lim, D. Young, Shin, S. Ho, Lee, M. - H., Malakhova, M., Kurinov, I., Wu, Q., Xu, J., Jiang, Y., Dong, Z., Liu, K., Lee, K. Yeong, Bae, K. Beom, Choi, B. Young, Deng, Y., Bode, A., and Dong, Z. (2016) A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. Oncotarget. 7, 35001-14

Banerjee, S., Capel, M., Kinsland, L., Kourinov, I., Murphy, F., Neau, D., Perry, K., Rajashankar, K. R., Salbego, C., Schuermann, J., Withrow, J., and Ealick, S. E. (2016) NE-CAT: Crystallography Beamlines for Challenging Structural Biology Research. 2016 Annual Meeting of the American Crystallographic Association, July 22-26, 2016

Zinder, J. C., Wasmuth, E. V., and Lima, C. D. (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3.. Mol Cell. 64, 734-745

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The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of eight member institutions:

Columbia University
Cornell University
Genentech
Harvard University
Massachusetts Institute of Technology
Memorial Sloan-Kettering Cancer Center
Rockefeller University
Yale University

Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS), a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.