Publications
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Using a fluorescent cytosine analogue tC(o) to probe the effect of the Y567 to Ala substitution on the preinsertion steps of dNMP incorporation by RB69 DNA polymerase. Biochemistry. 51, 4609-17
(2012) Structural insights into complete metal ion coordination from ternary complexes of B family RB69 DNA polymerase. Biochemistry. 50, 9114-24
(2011) Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. J Am Chem Soc. 133, 10003-5
(2011) Bidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymerase. Protein Sci. 21, 447-51
(2012) Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Nucleic Acids Res. 41, 9077-89
(2013) Contribution of partial charge interactions and base stacking to the efficiency of primer extension at and beyond abasic sites in DNA. Biochemistry. 51, 4922-31
(2012) (2014) Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51, 1476-85
(2012) DNA mismatch synthesis complexes provide insights into base selectivity of a B family DNA polymerase. J Am Chem Soc. 135, 193-202
(2013) Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry. 51, 4343-53
(2012) (2014) (2011) SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J Mol Biol. 433, 166880
(2021) Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1. Biochemistry. 62, 2934-2951
(2023) Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1. Arch Biochem Biophys. 691, 108477
(2020) Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus. J Biol Chem. 287, 8904-11
(2012) Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell. 152, 276-89
(2013) Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc Natl Acad Sci U S A. 10.1073/pnas.2115001118
(2021) Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 14, 5209
(2023) Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev Cell. 28, 19-29
(2014) (2016) Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance. Proc Natl Acad Sci U S A. 114, 4394-4399
(2017) (2011) Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief. Nat Commun. 15, 10738
(2024) Structures of human ENT1 in complex with adenosine reuptake inhibitors. Nat Struct Mol Biol. 26, 599-606
(2019)