Publications
Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR. Biochemistry. 54, 5867-77
(2015) Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife. 10.7554/eLife.25541
(2017) Peptide design by optimization on a data-parameterized protein interaction landscape. Proc Natl Acad Sci U S A. 115, E10342-E10351
(2018) Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture. J Biol Chem. 282, 34904-12
(2007) 2.0 Å resolution crystal structure of human polκ reveals a new catalytic function of N-clasp in DNA replication.. Sci Rep. 8, 15125
(2018) (2014) Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1. PLoS One. 13, e0199942
(2018) Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions. Biochemistry. 57, 3480-3492
(2018) (2013) Dual Ca-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol. 2, 240
(2019) Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 110, 5010-5
(2013) Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol. 19, 701-6
(2012) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Res. 10.1038/s41422-019-0272-2
(2020) Second Messenger cA Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Mol Cell. 75, 933-943.e6
(2019) CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA Cleavage with ApA>p Formation Terminating RNase Activity. Mol Cell. 75, 944-956.e6
(2019) Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 3, e02362
(2014) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science. 350, aab4070
(2015) 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell. 168, 1015-1027.e10
(2017) The role of distant mutations and allosteric regulation on LovD active site dynamics. Nat Chem Biol. 10, 431-6
(2014) N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes. Proc Natl Acad Sci U S A. 112, 13318-23
(2015) Crystal structures of human SIRT3 displaying substrate-induced conformational changes. J Biol Chem. 284, 24394-405
(2009) (2007) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem. 281, 25006-10
(2006) (2009) (2021)