Publications
Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51, 1476-85
(2012) Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Nucleic Acids Res. 41, 9077-89
(2013) Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry. 51, 4343-53
(2012) (2011) (2011) SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function. J Mol Biol. 433, 166880
(2021) Inhibition, crystal structures, and in-solution oligomeric structure of aldehyde dehydrogenase 9A1. Arch Biochem Biophys. 691, 108477
(2020) Epstein-Barr Virus Encoded BCL2, BHRF1, Downregulates Autophagy by Noncanonical Binding of BECN1. Biochemistry. 62, 2934-2951
(2023) Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5. Cell. 152, 276-89
(2013) Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies). Proc Natl Acad Sci U S A. 10.1073/pnas.2115001118
(2021) Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 14, 5209
(2023) (2011) Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance. Proc Natl Acad Sci U S A. 114, 4394-4399
(2017) Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev Cell. 28, 19-29
(2014) (2016) Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus. J Biol Chem. 287, 8904-11
(2012) Structures of human ENT1 in complex with adenosine reuptake inhibitors. Nat Struct Mol Biol. 26, 599-606
(2019) Structural analysis of an open active site conformation of nonheme iron halogenase CytC3. J Am Chem Soc. 131, 4872-9
(2009) P(I) Release Limits the Intrinsic and RNA-Stimulated ATPase Cycles of DEAD-Box Protein 5 (Dbp5). J Mol Biol. 428, 492-508
(2016) Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 348, 1155-60
(2015) KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Structure. 24, 1795-1801
(2016) Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc Natl Acad Sci U S A. 107, 16863-8
(2010) (2016) (2017) (2024)