Publications
The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage. Front Immunol. 11, 1529
(2020) Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry. 10.1021/acs.biochem.7b00638
(2017) Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis. J Biol Chem. 287, 6840-50
(2012) Structural basis of the alternating-access mechanism in a bile acid transporter. Nature. 505, 569-73
(2014) (2014) (2022) (2015) cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol Cell. 81, 739-755.e7
(2021) Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins. ACS Infect Dis. 5, 250-259
(2019) Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife. 10.7554/eLife.09832
(2015) NS3 from HCV strain JFH-1 is an unusually robust helicase that is primed to bind and unwind viral RNA. J Virol. 10.1128/JVI.01253-17
(2017) Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis. Bioorg Med Chem Lett. 10.1016/j.bmcl.2024.130026
(2024) The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. 10.1038/nature23484
(2017) Structural basis for the recognition of the S2, S5-phosphorylated RNA polymerase II CTD by the mRNA anti-terminator protein hSCAF4. FEBS Lett. 10.1002/1873-3468.14256
(2021) (2009) X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA.. Biomolecules. 10.3390/biom13091310
(2023) Involvement of the β3-α3 loop of the proline dehydrogenase domain in allosteric regulation of membrane association of proline utilization A.. Biochemistry. 52, 4482-91
(2013) Structural insights into drug development strategy targeting EGFR T790M/C797S. Oncotarget. 9, 13652-13665
(2018) Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host Microbe. 21, 220-230
(2017) Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell. 36, 39-50
(2009) Carbon Dioxide Capture at Nucleophilic Hydroxide Sites in Oxidation-Resistant Cyclodextrin-Based Metal-Organic Frameworks. Angew Chem Int Ed Engl. 61, e202206718
(2022) Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. PLoS One. 13, e0195048
(2018) (2013) Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter. Structure. 10.1016/j.str.2020.06.009
(2020) (2012)