Publications
The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J Biol Chem. 295, 10511-10521
(2020) Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. PLoS One. 14, e0226113
(2019) Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl Acad Sci U S A. 109, 17966-71
(2012) Structure and conformational dynamics of toxin A. Life Sci Alliance. 10.26508/lsa.202201383
(2022) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Mol Cell. 60, 319-27
(2015) Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.. Proc Natl Acad Sci U S A. 10.1073/pnas.2002486118
(2021) (2010) Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat Commun. 14, 4196
(2023) Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome. Antibiotics (Basel). 10.3390/antibiotics10040390
(2021) Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography. Nature. 499, 364-8
(2013) A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO. Joule. 3, 595-611
(2019) Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev. 29, 1326-40
(2015) Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization. Proc Natl Acad Sci U S A. 104, 15358-63
(2007) N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors. J Cell Sci. 126, 186-95
(2013) Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc Natl Acad Sci U S A. 113, E1190-9
(2016) Structure of the full-length Clostridium difficile toxin B. Nat Struct Mol Biol. 10.1038/s41594-019-0268-0
(2019) Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity. 55, 2135-2148.e6
(2022) (2014) Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. Sci Rep. 12, 9028
(2022) Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase. ACS Chem Biol. 11, 889-99
(2016) X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate. J Biol Chem. 294, 12405-12414
(2019) Terpene Synthases: One Fold, Many Products. Ph.D. thesis, University of Pennsylvania, Philadelphia, Pennsylvania
(2016) The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 10.7554/eLife.45403
(2019) Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS-family transposition. Elife. 10.7554/eLife.39611
(2018) (2016)