Publications

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Journal Article
Bubenik, M., Mader, P., Mochirian, P., Vallée, F., Clark, J., Truchon, J. - F., Perryman, A. L., Pau, V., Kurinov, I., Zahn, K. E., Leclaire, M. - E., Papp, R., Mathieu, M. - C., Hamel, M., Duffy, N. M., Godbout, C., Casas-Selves, M., Falgueyret, J. - P., Baruah, P. S., Nicolas, O., Stocco, R., Poirier, H., Martino, G., Fortin, A. Bonneau, Roulston, A., Chefson, A., Dorich, S., St-Onge, M., Patel, P., Pellerin, C., Ciblat, S., Pinter, T., Barabé, F., Bakkouri, M. El, Parikh, P., Gervais, C., Sfeir, A., Mamane, Y., Morris, S. J., W Black, C., Sicheri, F., and Gallant, M. (2022) Identification of , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.. J Med Chem. 10.1021/acs.jmedchem.2c00998
Wang, X., Allen, S., Blake, J. F., Bowcut, V., Briere, D. M., Calinisan, A., Dahlke, J. R., Fell, J. B., Fischer, J. P., Gunn, R. J., Hallin, J., Laguer, J., J Lawson, D., Medwid, J., Newhouse, B., Nguyen, P., O'Leary, J. M., Olson, P., Pajk, S., Rahbaek, L., Rodriguez, M., Smith, C. R., Tang, T. P., Thomas, N. C., Vanderpool, D., Vigers, G. P., Christensen, J. G., and Marx, M. A. (2021) Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor. J Med Chem. 10.1021/acs.jmedchem.1c01688
Ahmad, M. Faiz, Huff, S. E., Pink, J., Alam, I., Zhang, A., Perry, K., Harris, M. E., Misko, T., Porwal, S. K., Oleinick, N. L., Miyagi, M., Viswanathan, R., and Dealwis, C. Godfrey (2015) Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 58, 9498-509
Dhatwalia, R., Singh, H., Solano, L. M., Oppenheimer, M., Robinson, R. M., Ellerbrock, J. F., Sobrado, P., and Tanner, J. J. (2012) Identification of the NAD(P)H binding site of eukaryotic UDP-galactopyranose mutase. J Am Chem Soc. 134, 18132-8
Yoon, J., Zhang, Y. Meng, Her, C., Grant, R. A., Ponomarenko, A. I., Ackermann, B. E., Hui, T., Lin, Y. - S., Debelouchina, G. T., and Shoulders, M. D. (2024) The immune-evasive proline-283 substitution in influenza nucleoprotein increases aggregation propensity without altering the native structure. Sci Adv. 10, eadl6144
Chandran, S. S., Ma, J., Klatt, M. G., Dündar, F., Bandlamudi, C., Razavi, P., Wen, H. Y., Weigelt, B., Zumbo, P., Fu, S. Ning, Banks, L. B., Yi, F., Vercher, E., Etxeberria, I., Bestman, W. D., Paula, A. Da Cruz, Aricescu, I. S., Drilon, A., Betel, D., Scheinberg, D. A., Baker, B. M., and Klebanoff, C. A. (2022) Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. 28, 946-957
Chandran, S. S., Ma, J., Klatt, M. G., Dündar, F., Bandlamudi, C., Razavi, P., Wen, H. Y., Weigelt, B., Zumbo, P., Fu, S. Ning, Banks, L. B., Yi, F., Vercher, E., Etxeberria, I., Bestman, W. D., Paula, A. Da Cruz, Aricescu, I. S., Drilon, A., Betel, D., Scheinberg, D. A., Baker, B. M., and Klebanoff, C. A. (2022) Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med. 28, 946-957
Rechkoblit, O., Delaney, J. C., Essigmann, J. M., and Patel, D. J. (2011) Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure. 19, 821-32
Nguyen, H. An, Hoffer, E. D., and Dunham, C. M. (2019) Importance of tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in tRNA for decoding. J Biol Chem. 10.1074/jbc.RA119.007410
Hellman, L. M., Foley, K. C., Singh, N. K., Alonso, J. A., Riley, T. P., Devlin, J. R., Ayres, C. M., Keller, G. L. J., Zhang, Y., Kooi, C. W. Vander, Nishimura, M. I., and Baker, B. M. (2018) Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Mol Ther. 10.1016/j.ymthe.2018.12.010
Bhardwaj, R., Lindinger, S., Neuberger, A., Nadezhdin, K. D., Singh, A. K., Cunha, M. R., Derler, I., Gyimesi, G., Reymond, J. - L., Hediger, M. A., Romanin, C., and Sobolevsky, A. I. (2020) Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv. 10.1126/sciadv.abe1508
Raymond, D. D., Stewart, S. M., Lee, J., Ferdman, J., Bajic, G., Do, K. T., Ernandes, M. J., Suphaphiphat, P., Settembre, E. C., Dormitzer, P. R., Del Giudice, G., Finco, O., Kang, T. Hyun, Ippolito, G. C., Georgiou, G., Kepler, T. B., Haynes, B. F., M Moody, A., Liao, H. - X., Schmidt, A. G., and Harrison, S. C. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 22, 1465-1469
Raymond, D. D., Stewart, S. M., Lee, J., Ferdman, J., Bajic, G., Do, K. T., Ernandes, M. J., Suphaphiphat, P., Settembre, E. C., Dormitzer, P. R., Del Giudice, G., Finco, O., Kang, T. Hyun, Ippolito, G. C., Georgiou, G., Kepler, T. B., Haynes, B. F., M Moody, A., Liao, H. - X., Schmidt, A. G., and Harrison, S. C. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 22, 1465-1469
Raymond, D. D., Stewart, S. M., Lee, J., Ferdman, J., Bajic, G., Do, K. T., Ernandes, M. J., Suphaphiphat, P., Settembre, E. C., Dormitzer, P. R., Del Giudice, G., Finco, O., Kang, T. Hyun, Ippolito, G. C., Georgiou, G., Kepler, T. B., Haynes, B. F., M Moody, A., Liao, H. - X., Schmidt, A. G., and Harrison, S. C. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 22, 1465-1469
Cao, Q., Shin, W. Shik, Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., and Jiang, L. (2018) Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.. Nat Chem. 10.1038/s41557-018-0147-z
Tayeb-Fligelman, E., Cheng, X., Tai, C., Bowler, J. T., Griner, S., Sawaya, M. R., Seidler, P. M., Jiang, Y. Xiao, Lu, J., Rosenberg, G. M., Salwinski, L., Abskharon, R., Zee, C. - T., Hou, K., Li, Y., Boyer, D. R., Murray, K. A., Falcon, G., Anderson, D. H., Cascio, D., Saelices, L., Damoiseaux, R., Guo, F., and Eisenberg, D. S. (2021) Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 10.1101/2021.03.05.434000
Di Costanzo, L., Ilies, M., Thorn, K. J., and Christianson, D. W. (2010) Inhibition of human arginase I by substrate and product analogues. Arch Biochem Biophys. 496, 101-8
Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weïwer, M., W An, F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. - L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. - L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63
Lavoie, H., Thevakumaran, N., Gavory, G., Li, J. J., Padeganeh, A., Guiral, S., Duchaine, J., Mao, D. Y. L., Bouvier, M., Sicheri, F., and Therrien, M. (2013) Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat Chem Biol. 9, 428-36
Tang, H., Zhang, J., Shi, K., Aihara, H., and Du, G. (2019) Insight into subtilisin E-S7 cleavage pattern based on crystal structure and hydrolysates peptide analysis. Biochem Biophys Res Commun. 10.1016/j.bbrc.2019.03.064
Wang, J., Dye, B. T., Rajashankar, K. R., Kurinov, I., and Schulman, B. A. (2009) Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Nat Struct Mol Biol. 16, 987-9
Subramanian, R., Wilson-Kubalek, E. M., Arthur, C. P., Bick, M. J., Campbell, E. A., Darst, S. A., Milligan, R. A., and Kapoor, T. M. (2010) Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell. 142, 433-43
Ziegler, S. J., Liu, C., Landau, M., Buzovetsky, O., Desimmie, B. A., Zhao, Q., Sasaki, T., Burdick, R. C., Pathak, V. K., Anderson, K. S., and Xiong, Y. (2018) Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies. PLoS One. 13, e0195048
Dong, G., Wearsch, P. A., Peaper, D. R., Cresswell, P., and Reinisch, K. M. (2009) Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer. Immunity. 30, 21-32
Kamtekar, S., Berman, A. J., Wang, J., Lázaro, J. M., de Vega, M., Blanco, L., Salas, M., and Steitz, T. A. (2004) Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29. Mol Cell. 16, 609-18

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