Publications
BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci. 26, 972-984
(2017) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5
(2019) Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov. 10.1158/2159-8290.CD-19-1006
(2019) Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. J Gen Physiol. 10.1085/jgp.201912422
(2020) Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity.. Elife. 10.7554/eLife.19273
(2017) Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell. 32, 259-75
(2008) Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 114, 8770-8775
(2017) Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 114, 8770-8775
(2017) Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 114, 8770-8775
(2017) Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway. Mol Cell. 44, 451-61
(2011) Argonaute-based programmable RNase as a tool for cleavage of highly-structured RNA. Nucleic Acids Res. 46, e98
(2018) (2010) Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists. Cell Chem Biol. 10.1016/j.chembiol.2023.07.002
(2023) Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4. Elife. 10.7554/eLife.18449
(2016) Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3. Cell Chem Biol. 31, 139-149.e14
(2024) An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Sci Transl Med. 10.1126/scitranslmed.abn6859
(2022) Antibiotic that inhibits -translation blocks binding of EF-Tu to tmRNA but not to tRNA. mBio. 10.1128/mbio.01461-23
(2023) Antibiotic that inhibits -translation blocks binding of EF-Tu to tmRNA but not to tRNA. mBio. 10.1128/mbio.01461-23
(2023) An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance. Science. 383, 721-726
(2024) Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.. Nat Chem. 4, 927-33
(2012) (2023) (2011) African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nat Microbiol. 3, 932-938
(2018) Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor. ACS Med Chem Lett. 8, 1287-1291
(2017) Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 17, 711-717
(2021)