Publications
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Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins. Structure. 10.1016/j.str.2020.12.013
(2021) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem. 283, 32045-55
(2008) Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib. PLoS One. 18, e0290872
(2023) Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core. J Med Chem. 10.1021/acs.jmedchem.0c00192
(2020) Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism.. Proc Natl Acad Sci U S A. 113, 4051-6
(2016) Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. EMBO J. 26, 891-901
(2007) Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 10.1016/j.chembiol.2022.11.003
(2022) (2014) (2018) Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv. 7, eabf4459
(2021) Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Science. 10.1126/science.abc5667
(2020) Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer. Nat Commun. 5, 3110
(2014) (2019) Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun. 14, 2338
(2023) (2021) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
(2022) Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1. Biochemistry. 52, 7618-27
(2013) (2017) Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun. 4, 2495
(2013) (2009) Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A. 111, 10404-10
(2014) Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases. Biochemistry. 50, 1808-17
(2011) Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition. Nat Commun. 10, 2452
(2019) Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife. 10.7554/eLife.70146
(2021) Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex. Comput Struct Biotechnol J. 20, 4921-4929
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