Publications

Found 177 results
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2019
Remillard, D., Buckley, D. L., Seo, H. - S., Ferguson, F. M., Dhe-Paganon, S., Bradner, J. E., and Gray, N. S. (2019) Dual Inhibition of TAF1 and BET Bromodomains from the BI-2536 Kinase Inhibitor Scaffold. ACS Med Chem Lett. 10, 1443-1449
Chen, S., Wiewiora, R. P., Meng, F., Babault, N., Ma, A., Yu, W., Qian, K., Hu, H., Zou, H., Wang, J., Fan, S., Blum, G., Pittella-Silva, F., Beauchamp, K. A., Tempel, W., Jiang, H., Chen, K., Skene, R. J., Zheng, Y. George, Brown, P. J., Jin, J., Luo, C., Chodera, J. D., and Luo, M. (2019) The dynamic conformational landscape of the protein methyltransferase SETD8. Elife. 10.7554/eLife.45403
2018
Murphy, F. (2018) Data Collection and Quality. CCP4/APS School in Macromolecular Crystallography: From data collection to structure refinement and beyond, June 18 - 25, 2018
Rugel, A., Tarpley, R. S., Lopez, A., Menard, T., Guzman, M. A., Taylor, A. B., Cao, X., Kovalskyy, D., Chevalier, F. D., Anderson, T. J. C., P Hart, J., LoVerde, P. T., and McHardy, S. F. (2018) Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents. ACS Med Chem Lett. 9, 967-973
Saotome, K., Singh, A. K., and Sobolevsky, A. I. (2018) Determining the Crystal Structure of TRPV6. in Calcium Entry Channels in Non-Excitable Cells, pp. 275-292, Calcium Entry Channels in Non-Excitable Cells, Boca Raton (FL), 10.1201/9781315152592-14
Ivanochko, D., Halabelian, L., Henderson, E., Savitsky, P., Jain, H., Marcon, E., Duan, S., Hutchinson, A., Seitova, A., Barsyte-Lovejoy, D., Filippakopoulos, P., Greenblatt, J., Lima-Fernandes, E., and Arrowsmith, C. H. (2018) Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Res. 10.1093/nar/gky1192
Lau, Y. - T. K., Baytshtok, V., Howard, T. A., Fiala, B. M., Johnson, J. L. M., Carter, L. P., Baker, D., Lima, C. D., and Bahl, C. D. (2018) Discovery and engineering of enhanced SUMO protease enzymes. J Biol Chem. 293, 13224-13233
Jang, J., Son, J., Park, E., Kosaka, T., Saxon, J. A., De Clercq, D. J. H., Choi, H. Geun, Tanizaki, J., Eck, M. J., Jänne, P. A., and Gray, N. S. (2018) Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 57, 11629-11633
Babault, N., Allali-Hassani, A., Li, F., Fan, J., Yue, A., Ju, K., Liu, F., Vedadi, M., Liu, J., and Jin, J. (2018) Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT). J Med Chem. 61, 1541-1551
Kono, M., Ochida, A., Oda, T., Imada, T., Banno, Y., Taya, N., Masada, S., Kawamoto, T., Yonemori, K., Nara, Y., Fukase, Y., Yukawa, T., Tokuhara, H., Skene, R., Sang, B. - C., Hoffman, I. D., Snell, G. P., Uga, K., Shibata, A., Igaki, K., Nakamura, Y., Nakagawa, H., Tsuchimori, N., Yamasaki, M., Shirai, J., and Yamamoto, S. (2018) Discovery of [cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent Selective and Orally Available Novel Retinoic Acid Receptor-R. J Med Chem. 10.1021/acs.jmedchem.8b00061
Do, T. D., Sangwan, S., de Almeida, N. E. C., Ilitchev, A. I., Giammona, M., Sawaya, M. R., Buratto, S. K., Eisenberg, D. S., and Bowers, M. T. (2018) Distal Amyloid β-Protein Fragments Template Amyloid Assembly.. Protein Sci. 10.1002/pro.3375
Garg, A., Goldgur, Y., Schwer, B., and Shuman, S. (2018) Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Res. 10.1093/nar/gky827
Yoder, N., and Gouaux, E. (2018) Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. PLoS One. 13, e0202134
Goodman, M. C., Xu, S., Rouzer, C. A., Banerjee, S., Ghebreselasie, K., Migliore, M., Piomelli, D., and Marnett, L. J. (2018) Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 10.1074/jbc.M117.802058
2017
Remillard, D., Buckley, D. L., Paulk, J., Brien, G. L., Sonnett, M., Seo, H. - S., Dastjerdi, S., Wühr, M., Dhe-Paganon, S., Armstrong, S. A., and Bradner, J. E. (2017) Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 56, 5738-5743
Pawluk, A., Shah, M., Mejdani, M., Calmettes, C., Moraes, T. F., Davidson, A. R., and Maxwell, K. L. (2017) Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. mBio. 10.1128/mBio.01751-17
Barnash, K. D., The, J., Norris-Drouin, J. L., Cholensky, S. H., Worley, B. M., Li, F., Stuckey, J. I., Brown, P. J., Vedadi, M., Arrowsmith, C. H., Frye, S. V., and James, L. I. (2017) Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS Comb Sci. 19, 161-172
Xiong, Y., Li, F., Babault, N., Dong, A., Zeng, H., Wu, H., Chen, X., Arrowsmith, C. H., Brown, P. J., Liu, J., Vedadi, M., and Jin, J. (2017) Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J Med Chem. 60, 1876-1891
Lv, Z., Yuan, L., Atkison, J. H., Aldana-Masangkay, G., Chen, Y., and Olsen, S. K. (2017) Domain alternation and active site remodeling are conserved structural features of ubiquitin E1. J Biol Chem. 292, 12089-12099
2016
Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. - I., Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., J Fromme, C., K Garcia, C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. José Barb, Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M., and Sliz, P. (2016) Data publication with the structural biology data grid supports live analysis. Nat Commun. 7, 10882
Lee, W. - G., Chan, A. H., Spasov, K. A., Anderson, K. S., and Jorgensen, W. L. (2016) Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. ACS Med Chem Lett. 7, 1156-1160
Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Nguyen, A. Thai- Quynh, Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 29, 90-103
Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. - H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 30, 173-81
Choi, P. H., Jo, J., Lin, Y. - C., Lin, M. - H., Chou, C. - Y., Dietrich, L. E. P., and Tong, L. (2016) A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nat Commun. 7, 12713
Vaisey, G., Miller, A. N., and Long, S. B. (2016) Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. Proc Natl Acad Sci U S A. 113, E7399-E7408

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