Publications
Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1.. Proc Natl Acad Sci U S A. 110, 19772-7
(2013) Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife. 10.7554/eLife.08504
(2015) (2015) Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J Am Chem Soc. 143, 623-627
(2021) The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell. 126, 893-904
(2006) Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science. 318, 459-63
(2007) Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J Mol Biol. 430, 337-347
(2018) Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response. Acta Crystallogr F Struct Biol Commun. 72, 863-869
(2016) Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 25, 827-835.e6
(2019) Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. ACS Infect Dis. 10.1021/acsinfecdis.0c00726
(2020) (2015) High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci. 23, 1629-39
(2014) (2023) Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression. Protein Sci. 24, 1695-701
(2015) HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues. Biochemistry. 49, 8929-36
(2010) Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry. 47, 13404-17
(2008) Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 48, 6423-30
(2009) Accurate design of megadalton-scale two-component icosahedral protein complexes. Science. 353, 389-94
(2016) Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 66, 181-9
(2010) The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus. J Virol. 83, 12215-28
(2009) Systematic enhancement of protein crystallization efficiency by bulk lysine-to-arginine (KR) substitution. Protein Sci. 33, e4898
(2024) NE-CAT: Crystallography Beamlines for Challenging Structural Biology Research. 2016 Annual Meeting of the American Crystallographic Association, July 22-26, 2016
(2016) The Critical Tools Needed To Deal with Challenging Structural Biology Projects. Chemistry Colloquium, Shiv Nadar University
(2018) Structural Biology in Drug Discovery. Calcutta University
(2021) The Critical Tools Needed To Deal with Challenging Crystallography. Department of Biophysics & Biophysical Chemistry, Johns Hopkins School of Medicine
(2019)