Publications
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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 13, 1891
(2022) CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 429, 1829-1839
(2017) Structure of a helicase-helicase loader complex reveals insights into the mechanism of bacterial primosome assembly. Nat Commun. 4, 2495
(2013) Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer. Nat Commun. 5, 3110
(2014) Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. EMBO J. 26, 891-901
(2007) Computational design of a red fluorophore ligase for site-specific protein labeling in living cells. Proc Natl Acad Sci U S A. 111, E4551-9
(2014) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
(2025) Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer. J Mol Biol. 10.1016/j.jmb.2018.11.030
(2018) Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2. Nat Commun. 14, 2338
(2023) Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity. 53, 106-114.e5
(2020) Termini restraining of small membrane proteins enables structure determination at near-atomic resolution. Sci Adv. 10.1126/sciadv.abe3717
(2020) Insights into the mechanistic role of the [Fe4S4] cubane in the A-cluster {[Fe4S4]-(SR)-[NipNid]} of acetyl-coenzyme A synthase. Chembiochem. 12, 1417-21
(2011) (2009) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68, 89-92
(2012) Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A. 111, 10404-10
(2014) Discovery and structural characterization of the D-box, a conserved TonB motif that couples an inner-membrane motor to outer-membrane transport. J Biol Chem. 300, 105723
(2024) (2020) Crystal structure of the DENR-MCT-1 complex revealed zinc-binding site essential for heterodimer formation. Proc Natl Acad Sci U S A. 116, 528-533
(2019) (2017) (2013) Crystal Structure of Keratin 1/10(C401A) 2B Heterodimer Demonstrates a Proclivity for the C-Terminus of Helix 2B to Form Higher Order Molecular Contacts. Yale J Biol Med. 93, 3-17
(2020) The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together. Cell. 129, 319-32
(2007) Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases. Biochemistry. 50, 1808-17
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