Publications
(2011)
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. 475, 96-100
(2011) Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One. 6, e24179
(2011) Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.. Protein Sci. 20, 996-1004
(2011) Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science. 332, 981-4
(2011) (2011) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 488, 404-8
(2012) Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM. J Biol Chem. 287, 18044-54
(2012) Shifting hydrogen bonds may produce flexible transmembrane helices. Proc Natl Acad Sci U S A. 109, 8121-6
(2012) Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase. Proc Natl Acad Sci U S A. 109, 14314-9
(2012) Strandwise translocation of a DNA glycosylase on undamaged DNA. Proc Natl Acad Sci U S A. 109, 1086-91
(2012) Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51, 6195-206
(2012) Structural and biochemical studies of the open state of Lys48-linked diubiquitin. Biochim Biophys Acta. 1823, 2046-56
(2012) Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis. Nucleic Acids Res. 40, 9340-55
(2012) Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proc Natl Acad Sci U S A. 109, 15235-40
(2012) Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51, 1476-85
(2012) Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl Acad Sci U S A. 109, 17966-71
(2012) Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2. Nat Struct Mol Biol. 19, 1372-7
(2012) Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 20, 185-95
(2012) Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). J Biol Chem. 287, 22317-27
(2012) Structural basis for specificity of TGFβ family receptor small molecule inhibitors.. Cell Signal. 24, 476-83
(2012) Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell. 47, 16-26
(2012) Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 287, 23790-807
(2012) (2012) (2012)