Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

Publication Type:

Journal Article

Authors:

St-Cyr, Daniel; Ceccarelli, Derek F; Orlicky, Stephen; van der Sloot, Almer M; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike

Source:

Sci Adv, Volume 7, Issue 44, p.eabi5797 (2021)

Abstract:

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PDB: 
7M2K
Detector: 
PILATUS
Beamline: 
24-ID-C