Publications
(2025) Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree. Acta Crystallogr F Struct Biol Commun. 81, 398-405
(2025) Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree. Acta Crystallogr D Struct Biol. 81, 511-523
(2025) The C-terminal extension of calprotectin mediates zinc chelation and modulates Staphylococcus aureus biomass accumulation. Protein Sci. 34, e70294
(2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
(2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
(2025) Design of facilitated dissociation enables timing of cytokine signalling. Nature. 10.1038/s41586-025-09549-z
(2025) Design of facilitated dissociation enables timing of cytokine signalling. Nature. 10.1038/s41586-025-09549-z
(2025) Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation. Eur J Med Chem. 304, 118519
(2025) Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7. Structure. 10.1016/j.str.2025.01.021
(2025) Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7. Structure. 10.1016/j.str.2025.01.021
(2025) Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis. Nat Chem. 10.1038/s41557-025-01738-7
(2025) A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Nat Commun. 16, 8461
(2025) Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity. Nat Commun. 16, 849
(2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
(2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
(2025) How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity. Sci Adv. 11, eady9156
(2025) Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation. Acta Crystallogr D Struct Biol. 81, 122-129
(2025) Identification and Exploration of a Series of SARS-Cov‑2 M Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group.. ACS Med Chem Lett. 16, 1935-1945
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
(2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846

