Publications
(2025) Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity. Nat Commun. 16, 849
(2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
(2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
(2025) How ATP and dATP reposition class III ribonucleotide reductase cone domains to regulate enzyme activity. Sci Adv. 11, eady9156
(2025) Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation. Acta Crystallogr D Struct Biol. 81, 122-129
(2025) Identification and Exploration of a Series of SARS-Cov‑2 M Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group.. ACS Med Chem Lett. 16, 1935-1945
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
(2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
(2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
(2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
(2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
(2025) Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome. Science. 388, eads9030
(2025) Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeon . Proc Natl Acad Sci U S A. 122, e2416971122
(2025) Pharmacologic interrogation of USP28 cellular function in p53 signaling. Cell Chem Biol. 32, 1166-1182.e27
(2025) A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface. mBio. 16, e0089225
(2025) Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.. Nat Struct Mol Biol. 10.1038/s41594-025-01592-8
(2025) Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif. Structure. 10.1016/j.str.2025.11.003
(2025) Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350. Immunity. 58, 295-308.e5
(2025) The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors. Nat Commun. 10.1038/s41467-025-66967-3
(2025) Structural basis for varying drug resistance of SARS-CoV-2 M E166 variants. mBio. 16, e0262424
(2025) Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3. Cell Rep. 10.1016/j.celrep.2025.116572
(2025) Structural diversity and oligomerization of bacterial ubiquitin-like proteins. Structure. 33, 1016-1026.e4
(2025) Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors. J Mol Biol. 437, 169224

