Publications

Found 1208 results
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2023
Larson, G., Windsor, P., Smithwick, E., Shi, K., Aihara, H., Damodaran, A. Rama, and Bhagi-Damodaran, A. (2023) Understanding ATP binding to DosS catalytic domain with a short ATP-lid. bioRxiv. 10.1101/2023.05.29.542785
Deng, Y., Song, X., Iyamu, I. D., Dong, A., Min, J., and Huang, R. (2023) A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B. 13, 4893-4905
Deng, Y., Song, X., Iyamu, I. D., Dong, A., Min, J., and Huang, R. (2023) A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B. 13, 4893-4905
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
Sankhala, R. S., Dussupt, V., Donofrio, G., Gromowski, G. D., De La Barrera, R. A., Larocca, R. A., Mendez-Rivera, L., Lee, A., Choe, M., Zaky, W., Mantus, G., Jensen, J. L., Chen, W. - H., Gohain, N., Bai, H., McCracken, M. K., Mason, R. D., Leggat, D., Slike, B. M., Tran, U., Jian, N., Abbink, P., Peterson, R., Mendes, E. Araujo, Franca, R. Freitas de, Calvet, G. Amaral, de Filippis, A. Maria Bisp, McDermott, A., Roederer, M., Hernandez, M., Albertus, A., Davidson, E., Doranz, B. J., Rolland, M., Robb, M. L., Lynch, R. M., Barouch, D. H., Jarman, R. G., Thomas, S. J., Modjarrad, K., Michael, N. L., Krebs, S. J., and M Joyce, G. (2023) Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes. Cell Rep. 42, 112942
2022
Bhardwaj, G., O'Connor, J., Rettie, S., Huang, Y. - H., Ramelot, T. A., Mulligan, V. Khipple, Alpkilic, G. Gokce, Palmer, J., Bera, A. K., Bick, M. J., Di Piazza, M., Li, X., Hosseinzadeh, P., Craven, T. W., Tejero, R., Lauko, A., Choi, R., Glynn, C., Dong, L., Griffin, R., van Voorhis, W. C., Rodriguez, J., Stewart, L., Montelione, G. T., Craik, D., and Baker, D. (2022) Accurate de novo design of membrane-traversing macrocycles. Cell. 10.1016/j.cell.2022.07.019
Bhardwaj, G., O'Connor, J., Rettie, S., Huang, Y. - H., Ramelot, T. A., Mulligan, V. Khipple, Alpkilic, G. Gokce, Palmer, J., Bera, A. K., Bick, M. J., Di Piazza, M., Li, X., Hosseinzadeh, P., Craven, T. W., Tejero, R., Lauko, A., Choi, R., Glynn, C., Dong, L., Griffin, R., van Voorhis, W. C., Rodriguez, J., Stewart, L., Montelione, G. T., Craik, D., and Baker, D. (2022) Accurate de novo design of membrane-traversing macrocycles. Cell. 10.1016/j.cell.2022.07.019
Doherty, E. E., Karki, A., Wilcox, X. E., Mendoza, H. G., Manjunath, A., Matos, V. Jauregui, Fisher, A. J., and Beal, P. A. (2022) ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site. Nucleic Acids Res. 10.1093/nar/gkac897
Johnson, A. G., Wein, T., Mayer, M. L., Duncan-Lowey, B., Yirmiya, E., Oppenheimer-Shaanan, Y., Amitai, G., Sorek, R., and Kranzusch, P. J. (2022) Bacterial gasdermins reveal an ancient mechanism of cell death. Science. 375, 221-225
Sun, Z. - W., Waybright, J. M., Beldar, S., Chen, L., Foley, C. A., Norris-Drouin, J. L., Lyu, T. - J., Dong, A., Min, J., Wang, Y. - P., James, L. I., and Wang, Y. (2022) Cdyl Deficiency Brakes Neuronal Excitability and Nociception through Promoting Kcnb1 Transcription in Peripheral Sensory Neurons. Adv Sci (Weinh). 9, e2104317
Clark, N. E., Katolik, A., Welch, A., Schorl, C., Holloway, S. P., Schuermann, J. P., P Hart, J., Taylor, A. B., Damha, M. J., and Fairbrother, W. G. (2022) Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product. Biochemistry. 10.1021/acs.biochem.2c00590
Yuan, L., Gao, F., Lv, Z., Nayak, D., Nayak, A., Bury, P. Dos Santos, Cano, K. E., Jia, L., Oleinik, N., Atilgan, F. Cansu, Ogretmen, B., Williams, K. M., Davies, C., Oualid, F. El, Wasmuth, E. V., and Olsen, S. K. (2022) Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6. Nat Commun. 13, 4880
Cao, L., Coventry, B., Goreshnik, I., Huang, B., Park, J. Sung, Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., Verstraete, K., Walsh, S. Thomas Rus, Bennett, N., Phal, A., Yang, A., Kozodoy, L., DeWitt, M., Picton, L., Miller, L., Strauch, E. - M., DeBouver, N. D., Pires, A., Bera, A. K., Halabiya, S., Hammerson, B., Yang, W., Bernard, S., Stewart, L., Wilson, I. A., Ruohola-Baker, H., Schlessinger, J., Lee, S., Savvides, S. N., K Garcia, C., and Baker, D. (2022) Design of protein binding proteins from target structure alone. Nature. 10.1038/s41586-022-04654-9
Cao, L., Coventry, B., Goreshnik, I., Huang, B., Park, J. Sung, Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., Verstraete, K., Walsh, S. Thomas Rus, Bennett, N., Phal, A., Yang, A., Kozodoy, L., DeWitt, M., Picton, L., Miller, L., Strauch, E. - M., DeBouver, N. D., Pires, A., Bera, A. K., Halabiya, S., Hammerson, B., Yang, W., Bernard, S., Stewart, L., Wilson, I. A., Ruohola-Baker, H., Schlessinger, J., Lee, S., Savvides, S. N., K Garcia, C., and Baker, D. (2022) Design of protein binding proteins from target structure alone. Nature. 10.1038/s41586-022-04654-9
Liu, H., Iketani, S., Zask, A., Khanizeman, N., Bednarova, E., Forouhar, F., Fowler, B., Hong, S. Jung, Mohri, H., Nair, M. S., Huang, Y., Tay, N. E. S., Lee, S., Karan, C., Resnick, S. J., Quinn, C., Li, W., Shion, H., Xia, X., Daniels, J. D., Bartolo-Cruz, M., Farina, M., Rajbhandari, P., Jurtschenko, C., Lauber, M. A., McDonald, T., Stokes, M. E., Hurst, B. L., Rovis, T., Chavez, A., Ho, D. D., and Stockwell, B. R. (2022) Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19. Nat Commun. 13, 1891
Chana, C. K., Maisonneuve, P., Posternak, G., Grinberg, N. G. A., Poirson, J., Ona, S. M., Ceccarelli, D. F., Mader, P., St-Cyr, D. J., Pau, V., Kurinov, I., Tang, X., Deng, D., Cui, W., Su, W., Kuai, L., Soll, R., Tyers, M., Röst, H. L., Batey, R. A., Taipale, M., Gingras, A. - C., and Sicheri, F. (2022) Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J Med Chem. 10.1021/acs.jmedchem.2c00509
Szychowski, J., Papp, R., Dietrich, E., Liu, B., Vallée, F., Leclaire, M. - E., Fourtounis, J., Martino, G., Perryman, A. L., Pau, V., Yin, S. Yun, Mader, P., Roulston, A., Truchon, J. - F., C Marshall, G., Diallo, M., Duffy, N. M., Stocco, R., Godbout, C., Bonneau-Fortin, A., Kryczka, R., Bhaskaran, V., Mao, D., Orlicky, S., Beaulieu, P., Turcotte, P., Kurinov, I., Sicheri, F., Mamane, Y., Gallant, M., and W Black, C. (2022) Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 10.1021/acs.jmedchem.2c00552
Szychowski, J., Papp, R., Dietrich, E., Liu, B., Vallée, F., Leclaire, M. - E., Fourtounis, J., Martino, G., Perryman, A. L., Pau, V., Yin, S. Yun, Mader, P., Roulston, A., Truchon, J. - F., C Marshall, G., Diallo, M., Duffy, N. M., Stocco, R., Godbout, C., Bonneau-Fortin, A., Kryczka, R., Bhaskaran, V., Mao, D., Orlicky, S., Beaulieu, P., Turcotte, P., Kurinov, I., Sicheri, F., Mamane, Y., Gallant, M., and W Black, C. (2022) Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 10.1021/acs.jmedchem.2c00552
Szychowski, J., Papp, R., Dietrich, E., Liu, B., Vallée, F., Leclaire, M. - E., Fourtounis, J., Martino, G., Perryman, A. L., Pau, V., Yin, S. Yun, Mader, P., Roulston, A., Truchon, J. - F., C Marshall, G., Diallo, M., Duffy, N. M., Stocco, R., Godbout, C., Bonneau-Fortin, A., Kryczka, R., Bhaskaran, V., Mao, D., Orlicky, S., Beaulieu, P., Turcotte, P., Kurinov, I., Sicheri, F., Mamane, Y., Gallant, M., and W Black, C. (2022) Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 10.1021/acs.jmedchem.2c00552
Xiong, X., Tian, S., Yang, P., Lebreton, F., Bao, H., Sheng, K., Yin, L., Chen, P., Zhang, J., Qi, W., Ruan, J., Wu, H., Chen, H., Breault, D. T., Wu, H., Earl, A. M., Gilmore, M. S., Abraham, J., and Dong, M. (2022) Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 185, 1157-1171.e22
Wang, F., Li, L., Dou, Y., Shi, R., Duan, X., Liu, H., Zhang, J., Liu, D. D., Wu, J., He, Y., Lan, J., Lu, B., Feng, H., and Yan, J. (2022) Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants. Emerg Microbes Infect. 11, 548-551

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