Publications
(2009) New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. J Med Chem. 52, 1388-407
(2009) OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure. 17, 1411-21
(2009) Profound asymmetry in the structure of the cAMP-free cAMP Receptor Protein (CRP) from Mycobacterium tuberculosis. J Biol Chem. 284, 8228-32
(2009) Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements. Bioorg Med Chem Lett. 19, 6131-4
(2009) Regulation of active site coupling in glutamine-dependent NAD(+) synthetase. Nat Struct Mol Biol. 16, 421-9
(2009) Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase. Biochemistry. 48, 6423-30
(2009) Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol. 387, 1211-28
(2009) Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1. J Biol Chem. 284, 1906-16
(2009) Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem. 284, 276-83
(2009) Structure of a switchable subtilisin complexed with a substrate and with the activator azide. Biochemistry. 48, 10389-94
(2009) Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science. 324, 1444-7
(2009) Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 113, 4381-90
(2009) Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 113, 4381-90
(2009) Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob Agents Chemother. 53, 5010-4
(2009) U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome. J Mol Biol. 389, 146-56
(2009) X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature. 462, 745-56
(2008) cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proc Natl Acad Sci U S A. 105, 8902-7
(2008) Conformational change of the AcrR regulator reveals a possible mechanism of induction. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64, 584-8
(2008) Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. Mol Cell. 29, 122-33
(2008) Engineering substrate preference in subtilisin: structural and kinetic analysis of a specificity mutant. Biochemistry. 47, 6628-36
(2008) Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol. 379, 505-19
(2008) PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proc Natl Acad Sci U S A. 105, 3274-9