Publications

Found 1281 results
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2026
Bachochin, M. J., McGuire, K. L., Cook, B. D., Ye, Q., Silletti, S., Corbett, K. D., Komives, E. A., and Herzik, M. A. (2026) An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial import. Structure. 34, 273-283.e6
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Kang, A., Joyce, E., Bera, A. K., Hanikel, N., Salike, S., Krishna, R., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., and Baker, D. (2026) Computational design of metallohydrolases. Nature. 649, 246-253
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Kang, A., Joyce, E., Bera, A. K., Hanikel, N., Salike, S., Krishna, R., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., and Baker, D. (2026) Computational design of metallohydrolases. Nature. 649, 246-253
McNellis, M. E., Del Pino, G. Gonzalez-, Serrano-Jiménez, J. A., Forster, E. R., Stoica, A. Ioana, Heldwein, E. E., and Shen, A. (2026) The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination. PLoS Biol. 24, e3003610
Bubenik, M., Mader, P., Orlicky, S., Perryman, A. L., Hamel, M., Godbout, C., Falgueyret, J. - P., Kurinov, I., Wong, C., Gingras, A. Claude, Mamane, Y., Zinda, M., Morris, S. J., Gallant, M., Sfeir, A., W Black, C., Durocher, D., Zimmermann, M., and Sicheri, F. (2026) Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.. ACS Med Chem Lett. 17, 433-440
Smil, D., Liu, Y., Xin, T., Kiyota, T., Aman, A., Grouleff, J., Hoffer, L., Joshi, D. C., Inanlou, M. R., Song, S., Mao, D. Y. L., Ogunjimi, A. A., Pau, V., Chini, F. D., Kurinov, I., Zhang, Y., Nguyen, A. Thu, Wrana, J. L., Sicheri, F., Attisano, L., Uehling, D., Al-awar, R., and Isaac, M. B. (2026) Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer. Eur J Med Chem. 311, 118798
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Landry, M. L., Malhotra, S., Beresini, M., Chan, C., Chan, E., de la Cruz, C. C., Endres, N. F., Evangelista, M., Gustafson, A., Hu, D., Hunsaker, T., Hsu, P., Izrayelit, Y., La, H., Larrocha, P. Saenz- Lope, Lian, Q., Merchant, M., Mao, J., Mroue, R., Oh, A., Plise, E., Shao, C., Siu, M., Tran, J. C., Wang, Y., Wang, W., Wei, B., Wong, S., Yen, C. - W., Zhou, Y., Purkey, H. E., Heffron, T. P., and Salphati, L. (2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
Huet-Calderwood, C., Fisher, O. S., Das, S., Su, V. L., Boggon, T. J., and Calderwood, D. A. (2026) Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression. Nat Commun. 10.1038/s41467-026-69595-7
Hu, H., Zhang, Q., Ma, X., Chu, H. - F., Wang, H., Guo, Y., Bai, Y., Wang, Q., Li, Z., Zhao, J., Lin, H., You, C., Li, X., Tong, L., and Chen, X. (2026) Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs. Nat Biotechnol. 10.1038/s41587-026-03040-4
Lee, G. Rie, Pellock, S. J., Norn, C., Tischer, D., Dauparas, J., Anishchenko, I., Mercer, J. A. M., Kang, A., Bera, A. K., Nguyen, H., Brackenbrough, E., Sankaran, B., Goreshnik, I., Vafeados, D., Roullier, N., Han, H. L., Coventry, B., Haddox, H. K., Liu, D. R., Yeh, A. Hsien- Wei, and Baker, D. (2026) Small-molecule binding and sensing with a designed protein family. Nat Commun. 10.1038/s41467-026-70953-8
Lee, G. Rie, Pellock, S. J., Norn, C., Tischer, D., Dauparas, J., Anishchenko, I., Mercer, J. A. M., Kang, A., Bera, A. K., Nguyen, H., Brackenbrough, E., Sankaran, B., Goreshnik, I., Vafeados, D., Roullier, N., Han, H. L., Coventry, B., Haddox, H. K., Liu, D. R., Yeh, A. Hsien- Wei, and Baker, D. (2026) Small-molecule binding and sensing with a designed protein family. Nat Commun. 10.1038/s41467-026-70953-8
Shibata, S., Wang, M. Y., Imasaki, T., Shigematsu, H., La Torre, D. Ugarte, Wei, Y., Jobichen, C., Hagio, H., Sivaraman, J., Sugita, Y., Endow, S. A., and Nitta, R. (2026) Structural analysis of a motor with increased mechanical output reveals new transitions in kinesin microtubule motility. Sci Rep. 16, 487
Bhuket, P. Ratnatilak, Eastwood, J. R. B., Qin, Z., Kessler, J. L., Li, Y., Katz, D., Whitby, F. G., Hill, C. P., Kirshenbaum, K., and S Yu, M. (2026) Structural and Positional Effects of Peptoid Residues on Triple Helix Stability. Biomacromolecules. 10.1021/acs.biomac.5c02232
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Blair, B., Waddle, C., Hokanson, C. A., Bruce, H. A., Singer, A. U., Tombak, E. - M., Gildemann, K., Tamberg, N., Kiiver, K., Ustav, M., Ma, Y., Colombo, L., Huang, L. Jun- Shen, Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2026) Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. Protein Sci. 35, e70462
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Blair, B., Waddle, C., Hokanson, C. A., Bruce, H. A., Singer, A. U., Tombak, E. - M., Gildemann, K., Tamberg, N., Kiiver, K., Ustav, M., Ma, Y., Colombo, L., Huang, L. Jun- Shen, Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2026) Tetravalent antibodies are more potent and efficacious erythropoiesis-stimulating agents than erythropoietin in vivo. Protein Sci. 35, e70462
2025
Primi, M. C., Tavares, M. T., Hatcher, J. M., Kang, H., Kresina, T. A. C., Chakraborty, S., Leroy, E., Schmoker, A. M., Jeon, H., Weisberg, E. L., Akatsu, T., Griffin, J. D., Scott, D. A., and Eck, M. J. (2025) Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. Eur J Med Chem. 302, 118274
Pavelich, I. J., Schureck, M. A., Srinivas, P., Blackburn, T. M., Wang, D., Hoffer, E. D., Boamah, M., Zaldana, K., Onuoha, N., Miles, S. J., Grabowicz, M., C Okafor, D., and Dunham, C. M. (2025) Antitoxin control of optimal transcriptional repression in the atypical HigB-HigA toxin-antitoxin system from Proteus vulgaris. Nucleic Acids Res. 10.1093/nar/gkaf610
Nuthanakanti, A., Korn, M., Levenson-Palmer, R., Wu, Y., Babu, N. Rajesh, Huang, X., Banh, R. S., Belasco, J. G., and Serganov, A. (2025) ApaH decaps NpN-capped RNAs in two alternative orientations. Nat Chem Biol. 10.1038/s41589-025-01991-4
Adams, J. J., Blazer, L. L., Chung, J., Karimi, M., Davidson, T., Bruce, H. A., Singer, A. U., Yang, N., Cardarelli, L., Pot, I., Colombo, L., Huang, L. Jun- Shen, Ma, Y., Michnick, S. W., Moe, O. W., and Sidhu, S. S. (2025) An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo. Protein Sci. 34, e70292
Simanshu, D. K., Xu, R., Stice, J. P., Czyzyk, D. J., Feng, S., Denson, J. - P., Riegler, E., Yang, Y., Zhang, C., Donovan, S., Smith, B. P., Abreu-Blanco, M., Chen, M., Feng, C., Fu, L., Rabara, D., Young, L. C., Dyba, M., Yan, W., Lin, K., Ghorbanpoorvalukolaie, S., Larsen, E. K., Malik, W., Champagne, A., Parker, K., Ju, J. Hyun, Jeknic, S., Esposito, D., Turner, D. M., Lightstone, F. C., Wang, B., Wehn, P. M., Wang, K., Stephen, A. G., Maciag, A. E., Hata, A. N., Sinkevicius, K. W., Nissley, D. V., Wallace, E. M., McCormick, F., and Beltran, P. J. (2025) BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.. Science. 10.1126/science.adq2004
Kröll-Hermi, A., Stoetzel, C., Etard, C., Halabelian, L., Schaefer, E., Scheidecker, S., Kahrizi, K., Payman, J., Geoffroy, V., Prasad, M., Obringer, C., Ruch, L., Girard, A., Zeng, H., Li, F., Plassard, D., Keime, C., Mattioli, F., Feger, C., Piton, A., Fujita, A., Matsumoto, N., Castro, M. Augusto Ar, Ae, K. Chong, Ruaud, L., Levy, J., Dozières, B., Tabet, A. - C., Wentzensen, I. M., Santiago-Sim, T., Yusupov, R., Tveten, K., Smeland, M. Falkenberg, Alkhunaizi, E., Cowing, G., Li, C., Wortmann, S. B., Feichtinger, R. G., Mayr, J. A., Gonorazky, H., Jing, G., Wang, X., Wang, J., Bierhals, T., Grinstein, L., Herget, T., Ruiz, A., Gabau, E., Kampmeier, A., Kassel, O., Kuechler, A., Platzer, K., Jamra, R. Abou, Woerner, A., Idleburg, M., Kircher, S. Gerit, Laccone, F., Golob, B., Peterlin, B., Čuturilo, G., Tasic, V., Kolvenbach, C. M., Hildebrandt, F., Ramos, L. L. P., Kok, F., Buck, C. Barbosa, van de Laar, I. M. B. H., de Man, S. A., Taşdelen, E., Sezer, A., Büke, A., Yavuz, Z., Çomoğlu, S. Selçuk, Costin, C., Them, F. Tran Mau, Lacaze, E., Courtin, T., Héron, D., Keren, B., Whalen, S., Roume, J., Yang, Y., Hoffer, M. J. V., van Haeringen, A., Najmabadi, H., Arrowsmith, C. H., Strähle, U., Dollfus, H., and Muller, J. (2025) Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability. Am J Hum Genet. 10.1016/j.ajhg.2025.10.014
Kröll-Hermi, A., Stoetzel, C., Etard, C., Halabelian, L., Schaefer, E., Scheidecker, S., Kahrizi, K., Payman, J., Geoffroy, V., Prasad, M., Obringer, C., Ruch, L., Girard, A., Zeng, H., Li, F., Plassard, D., Keime, C., Mattioli, F., Feger, C., Piton, A., Fujita, A., Matsumoto, N., Castro, M. Augusto Ar, Ae, K. Chong, Ruaud, L., Levy, J., Dozières, B., Tabet, A. - C., Wentzensen, I. M., Santiago-Sim, T., Yusupov, R., Tveten, K., Smeland, M. Falkenberg, Alkhunaizi, E., Cowing, G., Li, C., Wortmann, S. B., Feichtinger, R. G., Mayr, J. A., Gonorazky, H., Jing, G., Wang, X., Wang, J., Bierhals, T., Grinstein, L., Herget, T., Ruiz, A., Gabau, E., Kampmeier, A., Kassel, O., Kuechler, A., Platzer, K., Jamra, R. Abou, Woerner, A., Idleburg, M., Kircher, S. Gerit, Laccone, F., Golob, B., Peterlin, B., Čuturilo, G., Tasic, V., Kolvenbach, C. M., Hildebrandt, F., Ramos, L. L. P., Kok, F., Buck, C. Barbosa, van de Laar, I. M. B. H., de Man, S. A., Taşdelen, E., Sezer, A., Büke, A., Yavuz, Z., Çomoğlu, S. Selçuk, Costin, C., Them, F. Tran Mau, Lacaze, E., Courtin, T., Héron, D., Keren, B., Whalen, S., Roume, J., Yang, Y., Hoffer, M. J. V., van Haeringen, A., Najmabadi, H., Arrowsmith, C. H., Strähle, U., Dollfus, H., and Muller, J. (2025) Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability. Am J Hum Genet. 10.1016/j.ajhg.2025.10.014

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