Publications

Found 356 results
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2025
Maurer, D. P., Vu, M., and Schmidt, A. G. (2025) Antigenic drift expands influenza viral escape pathways from recalled humoral immunity. Immunity. 58, 716-727.e6
Jangra, M., Travin, D. Y., Aleksandrova, E. V., Kaur, M., Darwish, L., Koteva, K., Klepacki, D., Wang, W., Tiffany, M., Sokaribo, A., Coombes, B. K., Vázquez-Laslop, N., Polikanov, Y. S., Mankin, A. S., and Wright, G. D. (2025) A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature. 10.1038/s41586-025-08723-7
Paul, M. E., Chen, D., Vish, K. J., Lartey, N. L., Hughes, E., Freeman, Z. T., Saunders, T. L., Stiegler, A. L., King, P. D., and Boggon, T. J. (2025) The C2 domain augments Ras GTPase-activating protein catalytic activity. Proc Natl Acad Sci U S A. 122, e2418433122
Torres, S. Vázquez, Valle, M. Benard, Mackessy, S. P., Menzies, S. K., Casewell, N. R., Ahmadi, S., Burlet, N. J., Muratspahić, E., Sappington, I., Overath, M. D., Rivera-de-Torre, E., Ledergerber, J., Laustsen, A. H., Boddum, K., Bera, A. K., Kang, A., Brackenbrough, E., Cardoso, I. A., Crittenden, E. P., Edge, R. J., Decarreau, J., Ragotte, R. J., Pillai, A. S., Abedi, M., Han, H. L., Gerben, S. R., Murray, A., Skotheim, R., Stuart, L., Stewart, L., Fryer, T. J. A., Jenkins, T. P., and Baker, D. (2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
Liu, H., Zask, A., Forouhar, F., Iketani, S., Williams, A., Vaz, D. R., Habashi, D., Choi, K., Resnick, S. J., Hong, S. Jung, Lovett, D. H., Bai, T., Chavez, A., Ho, D. D., and Stockwell, B. R. (2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
Streeter, O., Shi, K., Vavra, J., Aihara, H., Ervasti, J. M., Evans, R., and Muretta, J. M. (2025) Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation. Acta Crystallogr D Struct Biol. 81, 122-129
Voland, R. W., Wang, H., Abruña, H. D., and Lancaster, K. M. (2025) Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeon . Proc Natl Acad Sci U S A. 122, e2416971122
Ackloo, S., Li, F., Szewczyk, M., Seitova, A., Loppnau, P., Zeng, H., Xu, J., Ahmad, S., Arnautova, Y. A., Baghaie, A. J., Beldar, S., Bolotokova, A., Centrella, P. A., Chau, I., Clark, M. A., Cuozzo, J. W., Dehghani-Tafti, S., Disch, J. S., Dong, A., Dumas, A., Feng, J. A., Ghiabi, P., Gibson, E., Gilmer, J., Goldman, B., Green, S. R., Guié, M. - A., Guilinger, J. P., Harms, N., Herasymenko, O., Houliston, S., Hutchinson, A., Kearnes, S., Keefe, A. D., Kimani, S. W., Kramer, T., Kutera, M., Kwak, H. A., Lento, C., Li, Y., Liu, J., Loup, J., Machado, R. A. C., Mulhern, C. J., Perveen, S., Righetto, G. L., Riley, P., Shrestha, S., Sigel, E. A., Silva, M., Sintchak, M. D., Slakman, B. L., Taylor, R. D., Thompson, J., Torng, W., Underkoffler, C., von Rechenberg, M., Walsh, R. T., Watson, I., Wilson, D. J., Wolf, E., Yadav, M., Yazdi, A. K., Zhang, J., Zhang, Y., Santhakumar, V., Edwards, A. M., Barsyte-Lovejoy, D., Schapira, M., Brown, P. J., Halabelian, L., and Arrowsmith, C. H. (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
2024
Huang, W., Baliga, C., Aleksandrova, E. V., Atkinson, G., Polikanov, Y. S., Vázquez-Laslop, N., and Mankin, A. S. (2024) Activity, structure, and diversity of Type II proline-rich antimicrobial peptides from insects. EMBO Rep. 25, 5194-5211
An, L., Said, M., Tran, L., Majumder, S., Goreshnik, I., Lee, G. Rie, Juergens, D., Dauparas, J., Anishchenko, I., Coventry, B., Bera, A. K., Kang, A., Levine, P. M., Alvarez, V., Pillai, A., Norn, C., Feldman, D., Zorine, D., Hicks, D. R., Li, X., Sanchez, M. Garcia, Vafeados, D. K., Salveson, P. J., Vorobieva, A. A., and Baker, D. (2024) Binding and sensing diverse small molecules using shape-complementary pseudocycles. Science. 385, 276-282
An, L., Said, M., Tran, L., Majumder, S., Goreshnik, I., Lee, G. Rie, Juergens, D., Dauparas, J., Anishchenko, I., Coventry, B., Bera, A. K., Kang, A., Levine, P. M., Alvarez, V., Pillai, A., Norn, C., Feldman, D., Zorine, D., Hicks, D. R., Li, X., Sanchez, M. Garcia, Vafeados, D. K., Salveson, P. J., Vorobieva, A. A., and Baker, D. (2024) Binding and sensing diverse small molecules using shape-complementary pseudocycles. Science. 385, 276-282
Owens, D. D. G., Maitland, M. E. R., Yazdi, A. Khalili, Song, X., Reber, V., Schwalm, M. P., Machado, R. A. C., Bauer, N., Wang, X., Szewczyk, M. M., Dong, C., Dong, A., Loppnau, P., Calabrese, M. F., Dowling, M. S., Lee, J., Montgomery, J. I., O'Connell, T. N., Subramanyam, C., Wang, F., Adamson, E. C., Schapira, M., Gstaiger, M., Knapp, S., Vedadi, M., Min, J., Lajoie, G. A., Barsyte-Lovejoy, D., Owen, D. R., Schild-Poulter, C., and Arrowsmith, C. H. (2024) A chemical probe to modulate human GID4 Pro/N-degron interactions. Nat Chem Biol. 10.1038/s41589-024-01618-0
Forker, K., Fleming, M. C., Pearce, K. H., Vaziri, C., Bowers, A. A., and Zhou, P. (2024) Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction. EMBO J. 10.1038/s44318-024-00140-2
Smith, C. R., Chen, D., Christensen, J. G., Coulombe, R., Féthière, J., Gunn, R. J., Hollander, J., Jones, B., Ketcham, J. M., Khare, S., Kuehler, J., J Lawson, D., Marx, M. A., Olson, P., Pearson, K. E., Ren, C., Tsagris, D., Ulaganathan, T., Veer, I. Van't, Wang, X., and Ivetac, A. (2024) Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J Med Chem. 67, 774-781
Sankhala, R. S., Lal, K. G., Jensen, J. L., Dussupt, V., Mendez-Rivera, L., Bai, H., Wieczorek, L., Mayer, S. V., Zemil, M., Wagner, D. A., Townsley, S. M., Hajduczki, A., Chang, W. C., Chen, W. - H., Donofrio, G. C., Jian, N., King, H. A. D., Lorang, C. G., Martinez, E. J., Rees, P. A., Peterson, C. E., Schmidt, F., Hart, T. J., Duso, D. K., Kummer, L. W., Casey, S. P., Williams, J. K., Kannan, S., Slike, B. M., Smith, L., Swafford, I., Thomas, P. V., Tran, U., Currier, J. R., Bolton, D. L., Davidson, E., Doranz, B. J., Hatziioannou, T., Bieniasz, P. D., Paquin-Proulx, D., Reiley, W. W., Rolland, M., Sullivan, N. J., Vasan, S., Collins, N. D., Modjarrad, K., Gromowski, G. D., Polonis, V. R., Michael, N. L., Krebs, S. J., and M Joyce, G. (2024) Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques. Nat Commun. 15, 200
Ray, R., Mohamed, F. Amokrane N., Maurer, D. P., Huang, J., Alpay, B. A., Ronsard, L., Xie, Z., Han, J., Fernandez-Quintero, M., Phan, Q. Anh, Ursin, R. L., Vu, M., Kirsch, K. H., Prum, T., Rosado, V. C., Bracamonte-Moreno, T., Okonkwo, V., Bals, J., McCarthy, C., Nair, U., Kanekiyo, M., Ward, A. B., Schmidt, A. G., Batista, F. D., and Lingwood, D. (2024) Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses. Immunity. 57, 1141-1159.e11
Rasool, S., Shomali, T., Truong, L., Croteau, N., Veyron, S., Bustillos, B. A., Springer, W., Fiesel, F. C., and Trempe, J. - F. (2024) Identification and structural characterization of small molecule inhibitors of PINK1. Sci Rep. 14, 7739
Zhang, Z., Fu, J., Rack, J. Gregor Mat, Li, C., Voorneveld, J., Filippov, D. V., Ahel, I., Luo, Z. - Q., and Das, C. (2024) Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain. Nat Commun. 15, 2452
Aleksandrova, E. V., Ma, C. - X., Klepacki, D., Alizadeh, F., Vázquez-Laslop, N., Liang, J. - H., Polikanov, Y. S., and Mankin, A. S. (2024) Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nat Chem Biol. 10.1038/s41589-024-01685-3
Gama, F. H. de Souza, Dutra, L. A., Hawgood, M., Reis, C. Vinícius, Serafim, R. A. M., Ferreira, M. A., Teodoro, B. V. M., Takarada, J. Emi, Santiago, A. S., Balourdas, D. - I., Nilsson, A. - S., Urien, B., Almeida, V. M., Gileadi, C., Ramos, P. Z., Salmazo, A., Vasconcelos, S. N. S., Cunha, M. R., Mueller, S., Knapp, S., Massirer, K. B., Elkins, J. M., Gileadi, O., Mascarello, A., Lemmens, B. B. L. G., Guimarães, C. R. W., Azevedo, H., and Couñago, R. M. (2024) Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.. J Med Chem. 67, 8609-8629
Wang, H., Cheng, C., Dal Santo, J. L., Shen, C. - H., Bylund, T., Henry, A. R., Howe, C. A., Hwang, J., Morano, N. C., Morris, D. J., Pletnev, S., Roark, R. S., Zhou, T., Hansen, B. T., Hoyt, F. H., Johnston, T. S., Wang, S., Zhang, B., Ambrozak, D. R., Becker, J. E., Bender, M. F., Changela, A., Chaudhary, R., Corcoran, M., Corrigan, A. R., Foulds, K. E., Guo, Y., Lee, M., Li, Y., Lin, B. C., Liu, T., Louder, M. K., Mandolesi, M., Mason, R. D., McKee, K., Nair, V., O'Dell, S., Olia, A. S., Ou, L., Pegu, A., Raju, N., Rawi, R., Roberts-Torres, J., Sarfo, E. K., Sastry, M., Schaub, A. J., Schmidt, S. D., Schramm, C. A., Schwartz, C. L., Smith, S. C., Stephens, T., Stuckey, J., Teng, I. - T., Todd, J. - P., Tsybovsky, Y., Van Wazer, D. J., Wang, S., Doria-Rose, N. A., Fischer, E. R., Georgiev, I. S., Hedestam, G. B. Karlsson, Sheng, Z., Woodward, R. A., Douek, D. C., Koup, R. A., Pierson, T. C., Shapiro, L., Shaw, G. M., Mascola, J. R., and Kwong, P. D. (2024) Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell. 187, 7214-7231.e23
Aziz, F., Reddy, K., Vega, V. Fernandez, Dey, R., Hicks, K. A., Rao, S., Jordan, L. Ortiz, Smith, E., Shumate, J., Scampavia, L., Carpino, N., Spicer, T. P., and French, J. B. (2024) Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. J Med Chem. 67, 1949-1960
Das, N. Krishna, Vogt, J., Patel, A., Banna, H. Al, and Koirala, D. (2024) Structural basis for a highly conserved RNA-mediated enteroviral genome replication. Nucleic Acids Res. 10.1093/nar/gkae627
Lee, K., Perry, K., Xu, M., Veillard, I., Kumar, R., Rao, T. Dharma, Rueda, B. R., Spriggs, D. R., and Yeku, O. O. (2024) Structural basis for antibody recognition of the proximal MUC16 ectodomain. J Ovarian Res. 17, 41
Aguilar, E. N., Sagar, S., Murray, B. R., Rajesh, C., Lei, E. K., Michaud, S. A., Goodlett, D. R., Caffrey, T. C., Grandgenett, P. M., Swanson, B., Brooks, T. M., Black, A. R., van Faassen, H., Hussack, G., Henry, K. A., Hollingsworth, M. A., Brooks, C. L., and Radhakrishnan, P. (2024) Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6. Mol Cancer Ther. 23, 836-853

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