Publications
(2025) Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability. Am J Hum Genet. 10.1016/j.ajhg.2025.10.014
(2025) A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature. 10.1038/s41586-025-08723-7
(2025) A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome. Nature. 10.1038/s41586-025-08723-7
(2025) CARD domains mediate anti-phage defence in bacterial gasdermin systems. Nature. 10.1038/s41586-024-08498-3
(2025) Crystal structure of a seven-substitution mutant of hydroxynitrile lyase from rubber tree. Acta Crystallogr F Struct Biol Commun. 81, 398-405
(2025) Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nat Commun. 16, 3580
(2025) Crystal structures of 40- and 71-substitution variants of hydroxynitrile lyase from rubber tree. Acta Crystallogr D Struct Biol. 81, 511-523
(2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
(2025) The effects of naturally occurring mutations on functionality of oxylipin metabolizing dehydrogenase reductase nine. J Biol Chem. 301, 110704
(2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
(2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
(2025) Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling. Proc Natl Acad Sci U S A. 122, e2501635122
(2025) Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling. Proc Natl Acad Sci U S A. 122, e2501635122
(2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
(2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
(2025) Identification and Exploration of a Series of SARS-Cov‑2 M Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group.. ACS Med Chem Lett. 16, 1935-1945
(2025) In vivo nucleotide excision repair by mycobacterial UvrD1 requires ATP hydrolysis but does not depend on cysteine disulfide-mediated dimerization and DNA unwinding. Nucleic Acids Res. 10.1093/nar/gkaf269
(2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
(2025) Molecular basis for noncanonical transcription initiation from NpA alarmones. Nat Chem Biol. 10.1038/s41589-025-02044-6
(2025) Molecular basis for noncanonical transcription initiation from NpA alarmones. Nat Chem Biol. 10.1038/s41589-025-02044-6
(2025) Molecular basis for noncanonical transcription initiation from NpA alarmones. Nat Chem Biol. 10.1038/s41589-025-02044-6
(2025) Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeon . Proc Natl Acad Sci U S A. 122, e2416971122
(2025) A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface. mBio. 16, e0089225
(2025) Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif. Structure. 10.1016/j.str.2025.11.003
(2025) Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350. Immunity. 58, 295-308.e5

