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Found 2909 results
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2025
Perera, Y. R., Enriquez, K. T., Rodriguez, A., Garcia, V., Akizuki, T., Naretto, A., Togashi, M., Guillen, R., Skaar, E. P., and Chazin, W. J. (2025) The C-terminal extension of calprotectin mediates zinc chelation and modulates Staphylococcus aureus biomass accumulation. Protein Sci. 34, e70294
Torres, S. Vázquez, Valle, M. Benard, Mackessy, S. P., Menzies, S. K., Casewell, N. R., Ahmadi, S., Burlet, N. J., Muratspahić, E., Sappington, I., Overath, M. D., Rivera-de-Torre, E., Ledergerber, J., Laustsen, A. H., Boddum, K., Bera, A. K., Kang, A., Brackenbrough, E., Cardoso, I. A., Crittenden, E. P., Edge, R. J., Decarreau, J., Ragotte, R. J., Pillai, A. S., Abedi, M., Han, H. L., Gerben, S. R., Murray, A., Skotheim, R., Stuart, L., Stewart, L., Fryer, T. J. A., Jenkins, T. P., and Baker, D. (2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
Broerman, A. J., Pollmann, C., Zhao, Y., Lichtenstein, M. A., Jackson, M. D., Tessmer, M. H., Ryu, W. Hee, Ogishi, M., Abedi, M. H., Sahtoe, D. D., Allen, A., Kang, A., De La Cruz, J., Brackenbrough, E., Sankaran, B., Bera, A. K., Zuckerman, D. M., Stoll, S., K Garcia, C., Praetorius, F., Piehler, J., and Baker, D. (2025) Design of facilitated dissociation enables timing of cytokine signalling. Nature. 10.1038/s41586-025-09549-z
Liu, H., Zask, A., Forouhar, F., Iketani, S., Williams, A., Vaz, D. R., Habashi, D., Choi, K., Resnick, S. J., Hong, S. Jung, Lovett, D. H., Bai, T., Chavez, A., Ho, D. D., and Stockwell, B. R. (2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
Miranda, R., Anson, F., Smith, S. T., Ultsch, M., Tenorio, C. A., Rougé, L., Farrell, B., Adaligil, E., Holden, J. K., Harris, S. F., and Dueber, E. C. (2025) Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7. Structure. 10.1016/j.str.2025.01.021
Tresco, B. I. C., J Y Wu, K., Ramkissoon, A., Aleksandrova, E. V., Purdy, M., N Y See, D., Liu, R. Y., Polikanov, Y. S., and Myers, A. G. (2025) Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis. Nat Chem. 10.1038/s41557-025-01738-7
Bergman, H. M., Fan, A. T., Jones, C. G., Rothenberger, A. J., Jha, K. K., Handford, R. C., Nelson, H. M., Liu, Y., and T Tilley, D. (2025) Discovery of an Interlocked and Interwoven Molecular Topology in Nanocarbons via Dynamic C-C Bond Formation. J Am Chem Soc. 147, 19132-19138
Nguyen, B. V., Özden, C., Dong, K., Koc, O. Can, Torres-Ocampo, A. P., Dziedzic, N., Flaherty, D., Huang, J., Sankara, S., Abromson, N. Lyn, Tomchick, D. R., Fissore, R. A., Chen, J., Garman, S. C., and Stratton, M. M. (2025) A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Nat Commun. 16, 8461
Ma, J., Ayres, C. M., Brambley, C. A., Chandran, S. S., Rosales, T. J., Perera, W. W. J. Gihan, Eldaly, B., Murray, W. T., Corcelli, S. A., Kovrigin, E. L., Klebanoff, C. A., and Baker, B. M. (2025) Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity. Nat Commun. 16, 849
Pallapati, A. R., Korkmaz, F., Rojekar, S., Sims, S., Misra, A., Gimenez-Roig, J., Gangadhar, A., Laurencin, V., Gumerova, A., Cheliadinova, U., Sultana, F., Vasilyeva, D., Cullen, L., Schuermann, J., Munitz, J., Kannangara, H., Parte, S., Pevnev, G., Burganova, G., Tumoglu, Z., Witztum, R., Wizman, S., Kramskiy, N., Igel, L., Sen, F., Ranzenigo, A., Macdonald, A., Hutchison, S., Teunissen, A. Jp, Burkart, H., Saxena, M., Ginzburg, Y., Goosens, K., Zhou, W., Ryu, V., Moldavski, O., Barak, O., Pazianas, M., Caminis, J., Bhasin, S., Fitzgerald, R., Kim, S. - M., Quinn, M., Haider, S., Appt, S., Frolinger, T., Rosen, C. J., Lizneva, D., Gupta, Y. K., Yuen, T., and Zaidi, M. (2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
Slezak, T., O'Leary, K. M., Li, J., Rohaim, A., Davydova, E. K., and Kossiakoff, A. A. (2025) Engineered protein G variants for multifunctional antibody-based assemblies. Protein Sci. 34, e70019
Ota, N., Davies, C. W., Kang, J., Yan, D., Scherl, A., Wong, A., Cook, R., Tao, X., Dunlap, D., Klabunde, S., Mantik, P., Mohanan, V., Lin, W. Y., McBride, J., Sadekar, S., Storek, K. M., Lupardus, P., Ye, Z., Wallweber, H. Ackerly, Kiefer, J. R., Xu, M., Chan, P., Nagapudi, K., Yi, T., and Koerber, J. T. (2025) Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling. Proc Natl Acad Sci U S A. 122, e2501635122
Hemmings, M., Zieliński, M., Golkar, T., Blanchet, J., Pistofidis, A., Munro, K., T Schmeing, M., D Bohle, S., and Berghuis, A. M. (2025) Enzyme-mediated aminoglycoside resistance without target mimicry. Commun Chem. 8, 258
Słabicki, M., Park, J., Nowak, R. P., Burman, S. S. Roy, Pellman, J., Zou, C., Razumkov, H., Carreiro, J., Rastogi, S., Goldstein, A., Nagiec, M. M., Donovan, K. A., Che, J., Hunkeler, M., Geng, Q., Hsu, C. - L., Lakshminarayan, M., Shu, C., Zon, R. L., Kozicka, Z., Park, P. M. C., Tsai, J. M., Yoon, H., Jones, L. H., Sperling, A. S., Gray, N. S., Fischer, E. S., and Ebert, B. L. (2025) Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 85, 3184-3201.e14
Stopper, D., Biermann, L., Watson, P. R., Li, J., König, B., Gaynes, M. N., de Carvalho, L. Pessanha, Klose, J., Hanl, M., Hamacher, A., Schäker-Hübner, L., Ramsbeck, D., Held, J., Christianson, D. W., Kassack, M. U., and Hansen, F. K. (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
Dussupt, V., Jensen, J. L., Thomas, P. V., Mendez-Rivera, L., Lal, K. G., McCrea, M. Zemil, Swafford, I., Hernandez, J., Sankhala, R. S., Rao, M., Arora, J., Hajduczki, A., Jian, N., Rees, P. A., De Leon, I. Showell-, Smith, G., Smith, L., Wasson, D., Schmid, A., Teng, I. - T., Zhou, T., Kwong, P. D., Currier, J. R., Reiley, W. W., Paquin-Proulx, D., Polonis, V. R., Collins, N. D., Michael, N. L., M Joyce, G., and Krebs, S. J. (2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
Hazari, A., Sawaya, M. R., Lee, H., Sajimon, M., Kim, H., Iii, W. A. Goddard, Eisenberg, D., and Raskatov, J. A. (2025) Formation of rippled β-sheets from mixed chirality linear and cyclic peptides-new structural motifs based on the pauling-corey rippled β-sheet.. Chem Sci. 16, 5907-5917
Streeter, O., Shi, K., Vavra, J., Aihara, H., Ervasti, J. M., Evans, R., and Muretta, J. M. (2025) Human dystrophin tandem calponin homology actin-binding domain crystallized in a closed-state conformation. Acta Crystallogr D Struct Biol. 81, 122-129
Clyde-Allen, E., Zmudzinski, M., Afsar, M., James, C., Nayak, A., Nayak, D., Bury, P. Dos Santos, Jochmans, D., Neyts, J., Scott, C. J., Olsen, S. K., Drag, M., and Williams, R. (2025) Identification and Exploration of a Series of SARS-Cov‑2 M Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group.. ACS Med Chem Lett. 16, 1935-1945
Olaoye, O. O., Erdogan, F., Gracia-Hernandez, M., Garcha, H. Kaur, Sedighi, A., Ashraf, Q. F., Nawar, N., Geletu, M., Seo, H. - S., Abdallah, D. I., Abdeldayem, A., Hassan, M. Murtaza, Dhe-Paganon, S., de Araujo, E. D., Villagra, A., and Gunning, P. T. (2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
Warren, G. M., and Shuman, S. (2025) In vivo nucleotide excision repair by mycobacterial UvrD1 requires ATP hydrolysis but does not depend on cysteine disulfide-mediated dimerization and DNA unwinding. Nucleic Acids Res. 10.1093/nar/gkaf269
Fraser, B. J., Young, N. J., Bender, B. J., Gahbauer, S., Ilyassov, O., Wilson, R. P., Li, Y., Seitova, A., Lourenço, A. Luiz, Chung, D. Hee, Bardine, C., Bénard, F., Shoichet, B. K., Craik, C. S., and Arrowsmith, C. H. (2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
Boeszoermenyi, A., Radeva, D. L., Schindler, S., Valadares, V., Das, K. M. Padmanab, Dubey, A., Viennet, T., Schmitt, M., Kast, P., Gelev, V. M., Stoyanov, N., Burdzhiev, N., Petrov, O., Ficarro, S., Marto, J., Geffken, E. A., Dhe-Paganon, S., Seo, H. - S., Alexander, N. D., Cooley, R. B., Mehl, R. A., Kovacs, H., Anklin, C., Bermel, W., Kuprov, I., Takeuchi, K., and Arthanari, H. (2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
Fullenkamp, C. R., Mehdi, S., Jones, C. P., Tenney, L., Pichling, P., Prestwood, P. R., Ferré-D'Amaré, A. R., Tiwary, P., and Schneekloth, J. S. (2025) Machine Learning-Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands. Angew Chem Int Ed Engl. 10.1002/anie.202505971
Aleksandrova, E. V., Syroegin, E. A., Basu, R. S., Vassilevski, A. A., Gagnon, M. G., and Polikanov, Y. S. (2025) Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome. Science. 388, eads9030

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