Publications

Found 575 results
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2022
Chen, W. - H., Kim, J. H., Bu, W., Board, N. L., Tsybovsky, Y., Wang, Y., Hostal, A., Andrews, S. F., Gillespie, R. A., Choe, M., Stephens, T., Yang, E. Sung, Pegu, A., Peterson, C. E., Fisher, B. E., Mascola, J. R., Pittaluga, S., McDermott, A. B., Kanekiyo, M., M Joyce, G., and Cohen, J. I. (2022) Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition. Immunity. 55, 2135-2148.e6
Herp, D., Ridinger, J., Robaa, D., Shinsky, S. A., Schmidtkunz, K., Yesiloglu, T. Z., Bayer, T., Steimbach, R. R., Herbst-Gervasoni, C. J., Merz, A., Romier, C., Sehr, P., Gunkel, N., Miller, A. K., Christianson, D. W., Oehme, I., Sippl, W., and Jung, M. (2022) First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement. Chembiochem. 10.1002/cbic.202200180
Sanchez, A. M., Jacewicz, A., and Shuman, S. (2022) Fission yeast Duf89 and Duf8901 are cobalt/nickel-dependent phosphatase-pyrophosphatases that act via a covalent aspartyl-phosphate intermediate. J Biol Chem. 10.1016/j.jbc.2022.101851
Smith, C. R., Aranda, R., Bobinski, T. P., Briere, D. M., Burns, A. C., Christensen, J. G., Clarine, J., Engstrom, L. D., Gunn, R. J., Ivetac, A., Jean-Baptiste, R., Ketcham, J. M., Kobayashi, M., Kuehler, J., Kulyk, S., J Lawson, D., Moya, K., Olson, P., Rahbaek, L., Thomas, N. C., Wang, X., Waters, L. M., and Marx, M. A. (2022) Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of -Deleted Cancers.. J Med Chem. 10.1021/acs.jmedchem.1c01900
Zeyen, P., Zeyn, Y., Herp, D., Mahmoudi, F., Yesiloglu, T. Z., Erdmann, F., Schmidt, M., Robaa, D., Romier, C., Ridinger, J., Herbst-Gervasoni, C. J., Christianson, D. W., Oehme, I., Jung, M., Krämer, O. H., and Sippl, W. (2022) Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 234, 114272
Amrhein, J. A., Beyett, T. S., Feng, W. W., Krämer, A., Weckesser, J., Schaeffner, I. K., Rana, J. K., Jänne, P. A., Eck, M. J., Knapp, S., and Hanke, T. (2022) Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J Med Chem. 65, 15679-15697
Fang, J., Jiang, J., Leichter, S. M., Liu, J., Biswal, M., Khudaverdyan, N., Zhong, X., and Song, J. (2022) Mechanistic basis for maintenance of CHG DNA methylation in plants. Nat Commun. 13, 3877
Beyett, T. S., To, C., Heppner, D. E., Rana, J. K., Schmoker, A. M., Jang, J., De Clercq, D. J. H., Gomez, G., Scott, D. A., Gray, N. S., Jänne, P. A., and Eck, M. J. (2022) Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun. 13, 2530
Beyett, T. S., To, C., Heppner, D. E., Rana, J. K., Schmoker, A. M., Jang, J., De Clercq, D. J. H., Gomez, G., Scott, D. A., Gray, N. S., Jänne, P. A., and Eck, M. J. (2022) Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun. 13, 2530
Chen, B., Perry, K., and Jin, R. (2022) Neutralizing epitopes on toxin A revealed by the structures of two camelid VHH antibodies. Front Immunol. 13, 978858
Shankar, S., Ramachandran, S., Tulsian, N., Radhakrishnan, S., Jobichen, C., and Sivaraman, J. (2022) A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. FEBS J. 10.1111/febs.16658
Son, J., Jang, J., Beyett, T. S., Eum, Y., Haikala, H. M., Verano, A., Lin, M., Hatcher, J. M., Kwiatkowski, N. P., Eser, P. Özden, Poitras, M. J., Wang, S., Xu, M., Gokhale, P. C., Cameron, M. D., Eck, M. J., Gray, N. S., and Jänne, P. A. (2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Res. 10.1158/0008-5472.CAN-21-2693
Son, J., Jang, J., Beyett, T. S., Eum, Y., Haikala, H. M., Verano, A., Lin, M., Hatcher, J. M., Kwiatkowski, N. P., Eser, P. Özden, Poitras, M. J., Wang, S., Xu, M., Gokhale, P. C., Cameron, M. D., Eck, M. J., Gray, N. S., and Jänne, P. A. (2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Res. 10.1158/0008-5472.CAN-21-2693
Lam, K. - H., Tremblay, J. M., Perry, K., Ichtchenko, K., Shoemaker, C. B., and Jin, R. (2022) Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. PLoS Pathog. 18, e1010169
Gero, T. W., Heppner, D. E., Beyett, T. S., To, C., Azevedo, S. C., Jang, J., Bunnell, T., Feru, F., Li, Z., Shin, B. Hee, Soroko, K. M., Gokhale, P. C., Gray, N. S., Jänne, P. A., Eck, M. J., and Scott, D. A. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 10.1016/j.bmcl.2022.128718
Gero, T. W., Heppner, D. E., Beyett, T. S., To, C., Azevedo, S. C., Jang, J., Bunnell, T., Feru, F., Li, Z., Shin, B. Hee, Soroko, K. M., Gokhale, P. C., Gray, N. S., Jänne, P. A., Eck, M. J., and Scott, D. A. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 10.1016/j.bmcl.2022.128718
Johnson, C. W., Seo, H. - S., Terrell, E. M., Yang, M. - H., KleinJan, F., Gebregiworgis, T., Gasmi-Seabrook, G. M. C., Geffken, E. A., Lakhani, J., Song, K., Bashyal, P., Popow, O., Paulo, J. A., Liu, A., Mattos, C., Marshall, C. B., Ikura, M., Morrison, D. K., Dhe-Paganon, S., and Haigis, K. M. (2022) Regulation of GTPase function by autophosphorylation. Mol Cell. 82, 950-968.e14
Hazari, A., Sawaya, M. R., Vlahakis, N., Johnstone, T. C., Boyer, D., Rodriguez, J., Eisenberg, D., and Raskatov, J. A. (2022) The rippled β-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey.. Chem Sci. 13, 8947-8952
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K. Joshua, Zhang, M., Zhao, D. Yanling, Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P. J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M. T., Greenblatt, J. F., and Min, J. (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 13, 5453
Vance, T. D. R., Yip, P., Jiménez, E., Li, S., Gawol, D., Byrnes, J., Usón, I., Ziyyat, A., and Lee, J. E. (2022) SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins. Commun Biol. 5, 984
Kozlov, G., Mattijssen, S., Jiang, J., Nyandwi, S., Sprules, T., Iben, J. R., Coon, S. L., Gaidamakov, S., Noronha, A. M., Wilds, C. J., Maraia, R. J., and Gehring, K. (2022) Structural basis of 3'-end poly(A) RNA recognition by LARP1. Nucleic Acids Res. 10.1093/nar/gkac696
Joseph, D., Nayak, S. Ranjan, and Penmatsa, A. (2022) Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter. EMBO J. 41, e110735
Frey, K. M., Bertoletti, N., Chan, A. H., Ippolito, J. A., Bollini, M., Spasov, K. A., Jorgensen, W. L., and Anderson, K. S. (2022) Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci. 9, 805187
Chen, B., Basak, S., Chen, P., Zhang, C., Perry, K., Tian, S., Yu, C., Dong, M., Huang, L., Bowen, M. E., and Jin, R. (2022) Structure and conformational dynamics of toxin A. Life Sci Alliance. 10.26508/lsa.202201383

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