Publications
Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site. J Biol Chem. 10.1016/j.jbc.2025.108310
(2025) The C2 domain augments Ras GTPase-activating protein catalytic activity. Proc Natl Acad Sci U S A. 122, e2418433122
(2025) CARD domains mediate anti-phage defence in bacterial gasdermin systems. Nature. 10.1038/s41586-024-08498-3
(2025) Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nat Commun. 16, 3580
(2025) Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nat Commun. 16, 3580
(2025) Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nat Commun. 16, 3580
(2025) Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. Nat Commun. 16, 3580
(2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
(2025) De novo designed proteins neutralize lethal snake venom toxins. Nature. 10.1038/s41586-024-08393-x
(2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
(2025) Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 16, 152
(2025) Discovery of a fluorinated macrobicyclic antibiotic through chemical synthesis. Nat Chem. 10.1038/s41557-025-01738-7
(2025) Engineered protein G variants for multifunctional antibody-based assemblies. Protein Sci. 34, e70019
(2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
(2025) Formation of rippled β-sheets from mixed chirality linear and cyclic peptides-new structural motifs based on the pauling-corey rippled β-sheet.. Chem Sci. 16, 5907-5917
(2025) Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae. Proc Natl Acad Sci U S A. 122, e2411833122
(2025) (2025) Nitrous oxide production via enzymatic nitroxyl from the nitrifying archaeon . Proc Natl Acad Sci U S A. 122, e2416971122
(2025) Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nat Commun. 16, 3596
(2025) Structure-guided discovery of viral proteins that inhibit host immunity. Cell. 10.1016/j.cell.2024.12.035
(2025) Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.. Nat Commun. 16, 1778
(2025) Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.. Nat Commun. 16, 1778
(2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
(2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
(2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
(2025)