Publications

Found 1163 results
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2021
Li, T., Stayrook, S. E., Tsutsui, Y., Zhang, J., Wang, Y., Li, H., Proffitt, A., Krimmer, S. G., Ahmed, M., Belliveau, O., Walker, I. X., Mudumbi, K. C., Suzuki, Y., Lax, I., Alvarado, D., Lemmon, M. A., Schlessinger, J., and Klein, D. E. (2021) Structural basis for ligand reception by anaplastic lymphoma kinase. Nature. 600, 148-152
Chichili, V. Priyanka R., Chew, T. Weng, Shankar, S., Er, S. Yin, Chin, C. Fei, Jobichen, C., Pan, C. Qiurong, Zhou, Y., Yeong, F. May, Low, B. Chuan, and Sivaraman, J. (2021) Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation. Proc Natl Acad Sci U S A. 10.1073/pnas.2014242118
Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M., and Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by toxin B. Sci Adv. 7, eabi4582
Rechkoblit, O., Johnson, R. E., Gupta, Y. K., Prakash, L., Prakash, S., and Aggarwal, A. K. (2021) Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase. Nat Commun. 12, 4020
Rechkoblit, O., Johnson, R. E., Gupta, Y. K., Prakash, L., Prakash, S., and Aggarwal, A. K. (2021) Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase. Nat Commun. 12, 4020
Kumar, S., Athreya, A., Gulati, A., Nair, R. Mony, Mahendran, I., Ranjan, R., and Penmatsa, A. (2021) Structural basis of inhibition of a transporter from Staphylococcus aureus, NorC, through a single-domain camelid antibody. Commun Biol. 4, 836
Pidathala, S., Mallela, A. Kumar, Joseph, D., and Penmatsa, A. (2021) Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun. 12, 2199
Pidathala, S., Mallela, A. Kumar, Joseph, D., and Penmatsa, A. (2021) Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters. Nat Commun. 12, 2199
Dempsey, D. R., Viennet, T., Iwase, R., Park, E., Henriquez, S., Chen, Z., Jeliazkov, J. R., Palanski, B. A., Phan, K. L., Coote, P., Gray, J. J., Eck, M. J., Gabelli, S. B., Arthanari, H., and Cole, P. A. (2021) The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 28, 858-868
Dempsey, D. R., Viennet, T., Iwase, R., Park, E., Henriquez, S., Chen, Z., Jeliazkov, J. R., Palanski, B. A., Phan, K. L., Coote, P., Gray, J. J., Eck, M. J., Gabelli, S. B., Arthanari, H., and Cole, P. A. (2021) The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 28, 858-868
Dempsey, D. R., Viennet, T., Iwase, R., Park, E., Henriquez, S., Chen, Z., Jeliazkov, J. R., Palanski, B. A., Phan, K. L., Coote, P., Gray, J. J., Eck, M. J., Gabelli, S. B., Arthanari, H., and Cole, P. A. (2021) The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 28, 858-868
Sander, C. L., Luu, J., Kim, K., Furkert, D., Jang, K., Reichenwallner, J., Kang, M. S., Lee, H. - J., Eger, B. T., Choe, H. - W., Fiedler, D., Ernst, O. P., Kim, Y. Ju, Palczewski, K., and Kiser, P. D. (2021) Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 10.1016/j.str.2021.10.002
York, N. J., Lockart, M. M., Sardar, S., Khadka, N., Shi, W., Stenkamp, R. E., Zhang, J., Kiser, P. D., and Pierce, B. S. (2021) Structure of 3-mercaptopropionic acid dioxygenase with a substrate analog reveals bidentate substrate binding at the iron center. J Biol Chem. 10.1016/j.jbc.2021.100492
Svetlov, M. S., Syroegin, E. A., Aleksandrova, E. V., Atkinson, G. C., Gregory, S. T., Mankin, A. S., and Polikanov, Y. S. (2021) Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat Chem Biol. 10.1038/s41589-020-00715-0
Green, M. N., Gangwar, S. Pal, Michard, E., Simon, A. A., Portes, M. Teresa, Barbosa-Caro, J., Wudick, M. M., Lizzio, M. A., Klykov, O., Yelshanskaya, M. V., Feijó, J. A., and Sobolevsky, A. I. (2021) Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4. Mol Cell. 10.1016/j.molcel.2021.05.025
Hu, D. X., Patel, S., Chen, H., Wang, S., Staben, S. T., Dimitrova, Y. N., Wallweber, H. Ackerly, Lee, J. Y., Chan, G. Ka Yan, Sneeringer, C. J., Prangley, M. S., Moffat, J. G., Wu, K. C., Schutt, L. K., Salphati, L., Pang, J., McNamara, E., Huang, H., Chen, Y., Wang, Y., Zhao, W., Lim, J., Murthy, A., and Siu, M. (2021) Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 10.1021/acs.jmedchem.1c01180
Hu, D. X., Patel, S., Chen, H., Wang, S., Staben, S. T., Dimitrova, Y. N., Wallweber, H. Ackerly, Lee, J. Y., Chan, G. Ka Yan, Sneeringer, C. J., Prangley, M. S., Moffat, J. G., Wu, K. C., Schutt, L. K., Salphati, L., Pang, J., McNamara, E., Huang, H., Chen, Y., Wang, Y., Zhao, W., Lim, J., Murthy, A., and Siu, M. (2021) Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 10.1021/acs.jmedchem.1c01180
Hu, D. X., Patel, S., Chen, H., Wang, S., Staben, S. T., Dimitrova, Y. N., Wallweber, H. Ackerly, Lee, J. Y., Chan, G. Ka Yan, Sneeringer, C. J., Prangley, M. S., Moffat, J. G., Wu, K. C., Schutt, L. K., Salphati, L., Pang, J., McNamara, E., Huang, H., Chen, Y., Wang, Y., Zhao, W., Lim, J., Murthy, A., and Siu, M. (2021) Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors. J Med Chem. 10.1021/acs.jmedchem.1c01180
Mieher, J. L., Schormann, N., Wu, R., Patel, M., Purushotham, S., Wu, H., Scoffield, J., and Deivanayagam, C. (2021) Structure-Function Characterization of Streptococcus intermedius Surface Antigen Pas. J Bacteriol. 203, e0017521
Mieher, J. L., Schormann, N., Wu, R., Patel, M., Purushotham, S., Wu, H., Scoffield, J., and Deivanayagam, C. (2021) Structure-Function Characterization of Streptococcus intermedius Surface Antigen Pas. J Bacteriol. 203, e0017521
Liu, D., Shao, Y., Piccirilli, J. A., and Weizmann, Y. (2021) Structures of artificially designed discrete RNA nanoarchitectures at near-atomic resolution. Sci Adv. 7, eabf4459
Maciunas, L. J., Porter, N., Lee, P. J., Gupta, K., and Loll, P. J. (2021) Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states. Acta Crystallogr D Struct Biol. 77, 1027-1039
Dubiella, C., Pinch, B. J., Koikawa, K., Zaidman, D., Poon, E., Manz, T. D., Nabet, B., He, S., Resnick, E., Rogel, A., Langer, E. M., Daniel, C. J., Seo, H. - S., Chen, Y., Adelmant, G., Sharifzadeh, S., Ficarro, S. B., Jamin, Y., da Costa, B. Martins, Zimmerman, M. W., Lian, X., Kibe, S., Kozono, S., Doctor, Z. M., Browne, C. M., Yang, A., Stoler-Barak, L., Shah, R. B., Vangos, N. E., Geffken, E. A., Oren, R., Koide, E., Sidi, S., Shulman, Z., Wang, C., Marto, J. A., Dhe-Paganon, S., Look, T., Zhou, X. Zhen, Lu, K. Ping, Sears, R. C., Chesler, L., Gray, N. S., and London, N. (2021) Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 10.1038/s41589-021-00786-7
Dubiella, C., Pinch, B. J., Koikawa, K., Zaidman, D., Poon, E., Manz, T. D., Nabet, B., He, S., Resnick, E., Rogel, A., Langer, E. M., Daniel, C. J., Seo, H. - S., Chen, Y., Adelmant, G., Sharifzadeh, S., Ficarro, S. B., Jamin, Y., da Costa, B. Martins, Zimmerman, M. W., Lian, X., Kibe, S., Kozono, S., Doctor, Z. M., Browne, C. M., Yang, A., Stoler-Barak, L., Shah, R. B., Vangos, N. E., Geffken, E. A., Oren, R., Koide, E., Sidi, S., Shulman, Z., Wang, C., Marto, J. A., Dhe-Paganon, S., Look, T., Zhou, X. Zhen, Lu, K. Ping, Sears, R. C., Chesler, L., Gray, N. S., and London, N. (2021) Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 10.1038/s41589-021-00786-7
Mitcheltree, M. J., Pisipati, A., Syroegin, E. A., Silvestre, K. J., Klepacki, D., Mason, J. D., Terwilliger, D. W., Testolin, G., Pote, A. R., J Y Wu, K., Ladley, R. Porter, Chatman, K., Mankin, A. S., Polikanov, Y. S., and Myers, A. G. (2021) A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 10.1038/s41586-021-04045-6

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