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2024

Nayak, D., Lv, D., Yuan, Y., Zhang, P., Hu, W., Nayak, A., Ruben, E. A., Lv, Z., Sung, P., Hromas, R., Zheng, G., Zhou, D., and Olsen, S. K. (2024) Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun. 15, 2743

Phelps, G. A., Cheramie, M. N., Fernando, D. M., Selchow, P., Meyer, C. J., Waidyarachchi, S. L., Dharuman, S., Liu, J., Meuli, M., Dal Molin, M., Killam, B. Y., Murphy, P. A., Reeve, S. M., Wilt, L. A., Anderson, S. M., Yang, L., Lee, R. B., Temrikar, Z. H., Lukka, P. B., Meibohm, B., Polikanov, Y. S., Hobbie, S. N., Böttger, E. C., Sander, P., and Lee, R. E. (2024) Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in abscessus. Proc Natl Acad Sci U S A. 121, e2314101120

Phelps, G. A., Cheramie, M. N., Fernando, D. M., Selchow, P., Meyer, C. J., Waidyarachchi, S. L., Dharuman, S., Liu, J., Meuli, M., Dal Molin, M., Killam, B. Y., Murphy, P. A., Reeve, S. M., Wilt, L. A., Anderson, S. M., Yang, L., Lee, R. B., Temrikar, Z. H., Lukka, P. B., Meibohm, B., Polikanov, Y. S., Hobbie, S. N., Böttger, E. C., Sander, P., and Lee, R. E. (2024) Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in abscessus. Proc Natl Acad Sci U S A. 121, e2314101120

Palani, S., Machida, Y., Alvey, J. R., Mishra, V., Welter, A. L., Cui, G., Bragantini, B., Botuyan, M. Victoria, Cong, A. T. Q., Mer, G., Schellenberg, M. J., and Machida, Y. J. (2024) Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes. Nat Commun. 15, 2064

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Sun, D., Storek, K. M., Tegunov, D., Yang, Y., Arthur, C. P., Johnson, M., Quinn, J. G., Liu, W., Han, G., Girgis, H. S., Alexander, M. Kate, Murchison, A. K., Shriver, S., Tam, C., Ijiri, H., Inaba, H., Sano, T., Yanagida, H., Nishikawa, J., Heise, C. E., Fairbrother, W. J., Tan, M. - W., Skelton, N., Sandoval, W., Sellers, B. D., Ciferri, C., Smith, P. A., Reid, P. C., Cunningham, C. N., Rutherford, S. T., and Payandeh, J. (2024) The discovery and structural basis of two distinct state-dependent inhibitors of BamA. Nat Commun. 15, 8718

Loll, P. J., Grasty, K. C., Shultis, D. D., Guzman, N. J., and Wiener, M. C. (2024) Discovery and structural characterization of the D-box, a conserved TonB motif that couples an inner-membrane motor to outer-membrane transport. J Biol Chem. 300, 105723

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Maciag, A. E., Stice, J. P., Wang, B., Sharma, A. K., Chan, A. H., Lin, K., Singh, D., Dyba, M., Yang, Y., Setoodeh, S., Smith, B. P., Ju, J. Hyun, Jeknic, S., Rabara, D., Zhang, Z., Larsen, E. K., Esposito, D., Denson, J. - P., Ranieri, M., Meynardie, M., Mehdizadeh, S., Alexander, P. A., Blanco, M. Abreu, Turner, D. M., Xu, R., Lightstone, F. C., Wong, K. - K., Stephen, A. G., Wang, K., Simanshu, D. K., Sinkevicius, K. W., Nissley, D. V., Wallace, E., McCormick, F., and Beltran, P. J. (2024) Discovery of BBO-8520, a first-in-class direct and covalent dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C. Cancer Discov. 10.1158/2159-8290.CD-24-0840

Smith, C. R., Chen, D., Christensen, J. G., Coulombe, R., Féthière, J., Gunn, R. J., Hollander, J., Jones, B., Ketcham, J. M., Khare, S., Kuehler, J., J Lawson, D., Marx, M. A., Olson, P., Pearson, K. E., Ren, C., Tsagris, D., Ulaganathan, T., Veer, I. Van't, Wang, X., and Ivetac, A. (2024) Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. J Med Chem. 67, 774-781

Kofoed, E. M., Aliagas, I., Crawford, T., Mao, J., Harris, S. F., Xu, M., Wang, S., Wu, P., Ma, F., Clark, K., Sims, J., Xu, Y., Peng, Y., Skippington, E., Yang, Y., Reeder, J., Ubhayakar, S., Baumgardner, M., Yan, Z., Chen, J., Park, S., Zhang, H., Yen, C. - W., Lorenzo, M., Skelton, N., Liang, X., Chen, L., Hoag, B., Li, C. Sing, Liu, Z., Wai, J., Liu, X., Liang, J., and Tan, M. Wah (2024) Discovery of GuaB inhibitors with efficacy against infection. mBio. 15, e0089724

Kofoed, E. M., Aliagas, I., Crawford, T., Mao, J., Harris, S. F., Xu, M., Wang, S., Wu, P., Ma, F., Clark, K., Sims, J., Xu, Y., Peng, Y., Skippington, E., Yang, Y., Reeder, J., Ubhayakar, S., Baumgardner, M., Yan, Z., Chen, J., Park, S., Zhang, H., Yen, C. - W., Lorenzo, M., Skelton, N., Liang, X., Chen, L., Hoag, B., Li, C. Sing, Liu, Z., Wai, J., Liu, X., Liang, J., and Tan, M. Wah (2024) Discovery of GuaB inhibitors with efficacy against infection. mBio. 15, e0089724

Kofoed, E. M., Aliagas, I., Crawford, T., Mao, J., Harris, S. F., Xu, M., Wang, S., Wu, P., Ma, F., Clark, K., Sims, J., Xu, Y., Peng, Y., Skippington, E., Yang, Y., Reeder, J., Ubhayakar, S., Baumgardner, M., Yan, Z., Chen, J., Park, S., Zhang, H., Yen, C. - W., Lorenzo, M., Skelton, N., Liang, X., Chen, L., Hoag, B., Li, C. Sing, Liu, Z., Wai, J., Liu, X., Liang, J., and Tan, M. Wah (2024) Discovery of GuaB inhibitors with efficacy against infection. mBio. 15, e0089724

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The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of eight member institutions:

Columbia University
Cornell University
Genentech
Harvard University
Massachusetts Institute of Technology
Memorial Sloan-Kettering Cancer Center
Rockefeller University
Yale University

Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS), a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.