Publications
Structure and function of a flavin-dependent S-monooxygenase from garlic (). J Biol Chem. 295, 11042-11055
(2020) Structure of a Zinc Porphyrin-Substituted Bacterioferritin and Photophysical Properties of Iron Reduction. Biochemistry. 59, 1618-1629
(2020) Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.. Cell Rep. 32, 107922
(2020) The trajectory of intrahelical lesion recognition and extrusion by the human 8-oxoguanine DNA glycosylase. Nat Commun. 11, 4437
(2020) The Trp triad within the V-domain of the receptor for advanced glycation end products modulates folding, stability and ligand binding. Biosci Rep. 10.1042/BSR20193360
(2020) Visualizing group II intron dynamics between the first and second steps of splicing. Nat Commun. 11, 2837
(2020) A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 10.7554/eLife.47110
(2019) A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife. 10.7554/eLife.47110
(2019) Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460. Chem Sci. 10, 3756-3764
(2019) Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens. J Am Chem Soc. 10.1021/jacs.9b01693
(2019) Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett. 10, 1266-1271
(2019) Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain. ACS Chem Biol. 10.1021/acschembio.8b00722
(2019) (2019) Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases. J Biol Chem. 10.1074/jbc.RA119.007535
(2019) Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System. Research (Wash D C). 2019, 5641746
(2019) Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site. Proc Natl Acad Sci U S A. 116, 17280-17289
(2019) Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants. J Mol Biol. 431, 576-592
(2019) Structural basis for the evolution of cyclic phosphodiesterase activity in the U6 snRNA exoribonuclease Usb1. Nucleic Acids Res. 10.1093/nar/gkz1177
(2019) Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase Aα.. Elife. 10.7554/eLife.44760
(2019) Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur J Med Chem. 183, 111673
(2019) Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking. Acta Crystallogr F Struct Biol Commun. 75, 652-656
(2019) Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J Biol Chem. 294, 16451-16464
(2019) Target highlights in CASP13: Experimental target structures through the eyes of their authors. Proteins. 87, 1037-1057
(2019) (2019) African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat. Nat Microbiol. 3, 932-938
(2018)