Publications
 (2025) Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models. J Clin Invest. 10.1172/JCI182702
 (2025) Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 85, 3184-3201.e14
 (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers  as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
 (2025) Identification and Exploration of a Series of SARS-Cov‑2 M Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group.. ACS Med Chem Lett. 16, 1935-1945
 (2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
 (2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
 (2025) Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. J Med Chem. 68, 19893-19907
 (2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
 (2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
 (2025) Leveraging relaxation-optimized H-C correlations in 4-F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins. Nat Chem. 17, 835-846
 (2025) Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome. Science. 388, eads9030
 (2025) Molecular basis for noncanonical transcription initiation from NpA alarmones. Nat Chem Biol. 10.1038/s41589-025-02044-6
 (2025) A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex. Sci Adv. 11, eadx5831
 (2025) Spectroscopy and crystallography define carotenoid oxygenases as a new subclass of mononuclear non-heme Fe enzymes. J Biol Chem. 301, 108444
 (2025) Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development.. Nat Struct Mol Biol. 10.1038/s41594-025-01592-8
 (2025) Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350. Immunity. 58, 295-308.e5
 (2025) Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350. Immunity. 58, 295-308.e5
 (2025) Structural basis for LZTR1 recognition of RAS GTPases for degradation. Science. 389, 1112-1117
 (2025) Structural diversity and oligomerization of bacterial ubiquitin-like proteins. Structure. 33, 1016-1026.e4
 (2025) Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors. J Mol Biol. 437, 169224
 (2025) Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.. Nat Commun. 16, 1778
 (2025) Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling.. Nat Commun. 16, 1778
 (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
 (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
 (2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112

