Publications

Found 1260 results
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2025
Słabicki, M., Park, J., Nowak, R. P., Burman, S. S. Roy, Pellman, J., Zou, C., Razumkov, H., Carreiro, J., Rastogi, S., Goldstein, A., Nagiec, M. M., Donovan, K. A., Che, J., Hunkeler, M., Geng, Q., Hsu, C. - L., Lakshminarayan, M., Shu, C., Zon, R. L., Kozicka, Z., Park, P. M. C., Tsai, J. M., Yoon, H., Jones, L. H., Sperling, A. S., Gray, N. S., Fischer, E. S., and Ebert, B. L. (2025) Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 85, 3184-3201.e14
Słabicki, M., Park, J., Nowak, R. P., Burman, S. S. Roy, Pellman, J., Zou, C., Razumkov, H., Carreiro, J., Rastogi, S., Goldstein, A., Nagiec, M. M., Donovan, K. A., Che, J., Hunkeler, M., Geng, Q., Hsu, C. - L., Lakshminarayan, M., Shu, C., Zon, R. L., Kozicka, Z., Park, P. M. C., Tsai, J. M., Yoon, H., Jones, L. H., Sperling, A. S., Gray, N. S., Fischer, E. S., and Ebert, B. L. (2025) Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation. Mol Cell. 85, 3184-3201.e14
Stopper, D., Biermann, L., Watson, P. R., Li, J., König, B., Gaynes, M. N., de Carvalho, L. Pessanha, Klose, J., Hanl, M., Hamacher, A., Schäker-Hübner, L., Ramsbeck, D., Held, J., Christianson, D. W., Kassack, M. U., and Hansen, F. K. (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
Stopper, D., Biermann, L., Watson, P. R., Li, J., König, B., Gaynes, M. N., de Carvalho, L. Pessanha, Klose, J., Hanl, M., Hamacher, A., Schäker-Hübner, L., Ramsbeck, D., Held, J., Christianson, D. W., Kassack, M. U., and Hansen, F. K. (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
Stopper, D., Biermann, L., Watson, P. R., Li, J., König, B., Gaynes, M. N., de Carvalho, L. Pessanha, Klose, J., Hanl, M., Hamacher, A., Schäker-Hübner, L., Ramsbeck, D., Held, J., Christianson, D. W., Kassack, M. U., and Hansen, F. K. (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
Stopper, D., Biermann, L., Watson, P. R., Li, J., König, B., Gaynes, M. N., de Carvalho, L. Pessanha, Klose, J., Hanl, M., Hamacher, A., Schäker-Hübner, L., Ramsbeck, D., Held, J., Christianson, D. W., Kassack, M. U., and Hansen, F. K. (2025) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing Properties. J Med Chem. 10.1021/acs.jmedchem.4c02373
Dussupt, V., Jensen, J. L., Thomas, P. V., Mendez-Rivera, L., Lal, K. G., McCrea, M. Zemil, Swafford, I., Hernandez, J., Sankhala, R. S., Rao, M., Arora, J., Hajduczki, A., Jian, N., Rees, P. A., De Leon, I. Showell-, Smith, G., Smith, L., Wasson, D., Schmid, A., Teng, I. - T., Zhou, T., Kwong, P. D., Currier, J. R., Reiley, W. W., Paquin-Proulx, D., Polonis, V. R., Collins, N. D., Michael, N. L., M Joyce, G., and Krebs, S. J. (2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
Dussupt, V., Jensen, J. L., Thomas, P. V., Mendez-Rivera, L., Lal, K. G., McCrea, M. Zemil, Swafford, I., Hernandez, J., Sankhala, R. S., Rao, M., Arora, J., Hajduczki, A., Jian, N., Rees, P. A., De Leon, I. Showell-, Smith, G., Smith, L., Wasson, D., Schmid, A., Teng, I. - T., Zhou, T., Kwong, P. D., Currier, J. R., Reiley, W. W., Paquin-Proulx, D., Polonis, V. R., Collins, N. D., Michael, N. L., M Joyce, G., and Krebs, S. J. (2025) First-generation N-terminal domain supersite public antibodies retain activity against Omicron-derived lineages and protect mice against Omicron BA.5 challenge. mBio. 16, e0103625
Hazari, A., Sawaya, M. R., Lee, H., Sajimon, M., Kim, H., Iii, W. A. Goddard, Eisenberg, D., and Raskatov, J. A. (2025) Formation of rippled β-sheets from mixed chirality linear and cyclic peptides-new structural motifs based on the pauling-corey rippled β-sheet.. Chem Sci. 16, 5907-5917
Olaoye, O. O., Erdogan, F., Gracia-Hernandez, M., Garcha, H. Kaur, Sedighi, A., Ashraf, Q. F., Nawar, N., Geletu, M., Seo, H. - S., Abdallah, D. I., Abdeldayem, A., Hassan, M. Murtaza, Dhe-Paganon, S., de Araujo, E. D., Villagra, A., and Gunning, P. T. (2025) Improved Pharmacokinetic Profiles of HDAC6 Inhibitors via Cap Group Modifications. J Med Chem. 10.1021/acs.jmedchem.5c00479
Duan, W., Kaushik, A., Unarta, I. C., Wu, Y., Liu, M. M. J., Weaver, J. W., Wang, B., Rice, W. J., Luciano, D. J., Belasco, J. G., Huang, X., Nudler, E., and Serganov, A. (2025) Molecular basis for noncanonical transcription initiation from NpA alarmones. Nat Chem Biol. 10.1038/s41589-025-02044-6
Schwartze, T. A., Morosky, S. A., Rosato, T. L., Henrickson, A., Lin, G., Hinck, C. S., Taylor, A. B., Olsen, S. K., Calero, G., Demeler, B., Roman, B. L., and Hinck, A. P. (2025) Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10. J Mol Biol. 437, 168935
Schwartze, T. A., Morosky, S. A., Rosato, T. L., Henrickson, A., Lin, G., Hinck, C. S., Taylor, A. B., Olsen, S. K., Calero, G., Demeler, B., Roman, B. L., and Hinck, A. P. (2025) Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10. J Mol Biol. 437, 168935
Schwartze, T. A., Morosky, S. A., Rosato, T. L., Henrickson, A., Lin, G., Hinck, C. S., Taylor, A. B., Olsen, S. K., Calero, G., Demeler, B., Roman, B. L., and Hinck, A. P. (2025) Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10. J Mol Biol. 437, 168935
Terayama, K., Furuzono, S., Fer, N., Yan, W., Young, L. C., Czyzyk, D. J., de Salazar, R. Goldstein, Sasaki, M., Uozumi, A., Konishi, M., Kanda, S., Sogawa, Y., Yamaguchi, M., Tsuji, T., Kuroyanagi, J., Hayashi, M., Ogura, Y., Simanshu, D. K., Kubota, K., Tanaka, J., and McCormick, F. (2025) Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.. Science. 389, 402-408
Lam, K. - H., Gao, L., Przykopanski, A., Chen, B., Huang, T., Krüger, M., Bartels, A. - M., Dorner, M. Bernhard, Perry, K., Dorner, B. Gertrud, Rummel, A., and Jin, R. (2025) A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex. Sci Adv. 11, eadx5831
Bratt, A. S., Kilgas, S., Guzman, M. I. Tarazona, Magin, R. S., Maisonet, I. Jaen, Starnbach, C. A., Teh, W. Pin, Varca, A. C., Hu, B., Guzman, E. Tarazona, Seo, H. - S., Dhe-Paganon, S., Girardi, N. M., Adelmant, G., Marto, J. A., Chowdhury, D., and Buhrlage, S. J. (2025) Pharmacologic interrogation of USP28 cellular function in p53 signaling. Cell Chem Biol. 32, 1166-1182.e27
Esler, M. A., Shi, K., Rollie, J. A., Delgado, R., Vishwakarma, J., Dabrowska, A., Prahlad, J., Moghadasi, S. Arad, Harris, R. S., and Aihara, H. (2025) Structural basis for varying drug resistance of SARS-CoV-2 M E166 variants. mBio. 16, e0262424
Alpsoy, A., Ipsaro, J. J., Skopelitis, D., Pal, S., Chung, F. S., Carpenter, S., Desmarais, J. J., Wu, X. S., Chang, K., DiMare, M. T., Harten, E., Bergman, S., Kinney, J. B., Engelman, J. A., Bhang, H. - E. C., Joshua-Tor, L., and Vakoc, C. R. (2025) Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3. Cell Rep. 10.1016/j.celrep.2025.116572
Montermoso, S., Eilers, G., Allen, A., Sharp, R., Hwang, Y., Bushman, F. D., Gupta, K., and Van Duyne, G. (2025) Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors. J Mol Biol. 437, 169224
Misra, A., Rahisuddin, R., Parihar, M., Arya, S., Viswanathan, T., Jackson, N., Qi, S., Chan, S. - H., Harris, R. S., Martinez-Sobrido, L., and Gupta, Y. K. (2025) Structural insights into the assembly and regulation of 2'-O RNA methylation by SARS-CoV-2 nsp16/nsp10. Structure. 33, 1027-1039.e4
Trasviña-Arenas, C. H., Dissanayake, U. C., Tamayo, N., Hashemian, M., Lin, W. - J., Demir, M., Hoyos-Gonzalez, N., Fisher, A. J., G Cisneros, A., Horvath, M. P., and David, S. S. (2025) Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nat Commun. 16, 3596
Trasviña-Arenas, C. H., Dissanayake, U. C., Tamayo, N., Hashemian, M., Lin, W. - J., Demir, M., Hoyos-Gonzalez, N., Fisher, A. J., G Cisneros, A., Horvath, M. P., and David, S. S. (2025) Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nat Commun. 16, 3596
Trasviña-Arenas, C. H., Dissanayake, U. C., Tamayo, N., Hashemian, M., Lin, W. - J., Demir, M., Hoyos-Gonzalez, N., Fisher, A. J., G Cisneros, A., Horvath, M. P., and David, S. S. (2025) Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nat Commun. 16, 3596
Yirmiya, E., Hobbs, S. J., Leavitt, A., Osterman, I., Avraham, C., Hochhauser, D., Madhala, B., Skovorodka, M., Tan, J. M. J., Toyoda, H. C., Chebotar, I., Itkin, M., Malitsky, S., Amitai, G., Kranzusch, P. J., and Sorek, R. (2025) Structure-guided discovery of viral proteins that inhibit host immunity. Cell. 10.1016/j.cell.2024.12.035

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